Senescence controls prostatic neoplasia driven by Pten loss - Archive ouverte HAL
Article Dans Une Revue Molecular & Cellular Oncology Année : 2019

Senescence controls prostatic neoplasia driven by Pten loss

Résumé

We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.

Domaines

Cancer
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Dates et versions

hal-02398234 , version 1 (24-11-2020)

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Maxime Parisotto, Elise Grelet, Rana El Bizri, Daniel Metzger. Senescence controls prostatic neoplasia driven by Pten loss. Molecular & Cellular Oncology, 2019, 6 (1), pp.1511205. ⟨10.1080/23723556.2018.1511205⟩. ⟨hal-02398234⟩
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