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Communication Dans Un Congrès Année : 2019

Numerical assessment of device-related thrombus formation triggered by the contact system

Franck Nicoud
Rodrigo Mendez
  • Fonction : Auteur
Alexandre Ranc
  • Fonction : Auteur
Muriel Giansily
  • Fonction : Auteur
Simon Mendez

Résumé

Thrombosis is a major concern in blood-coated medical devices. In the present study, pro-coagulant reactions including the contact activation system are coupled with a fluid solver as well as a recently proposed thrombus formation model. The resulting biochemical/fluid model is applied to a backward facing step configuration, a flow configuration that frequently appears in medical devices. Simulations show that the contact system induces a large concentration of thrombin is the recirculation zone without the need of an a priori knowledge of the thrombus location. Platelets are then chemically activated and generate a thrombus whose both position and growth rate are in good agreement with the experimental data available.
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Dates et versions

hal-02397305 , version 1 (06-12-2019)

Identifiants

  • HAL Id : hal-02397305 , version 1

Citer

Franck Nicoud, Rodrigo Mendez, Alexandre Ranc, Muriel Giansily, Didier Lucor, et al.. Numerical assessment of device-related thrombus formation triggered by the contact system. International Conference on Computational & Mathematical Biomedical Engineering, P. Nithiarasu, M. Ohta, M. Oshima, Jun 2019, Sendai, Japan. ⟨hal-02397305⟩
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