Biosensors to diagnose Chagas disease: A review
Résumé
Chagas disease (CD), which mostly affects underprivileged people, has turned into one 9 of Latin America's main public health problems. Prevention of the disease requires early diagnosis, 10 initiation of therapy, and regular blood monitoring of the infected individual. However, the majority 11 of the infections go undiagnosed because of general mild symptoms and lack of access to medical 12 care. Therefore, more affordable and accessible detection technologies capable of providing early 13 diagnosis and parasite load measurements in settings where CD is prevalent are needed to enable 14 enhanced intervention strategies. This review discusses currently available detection technologies 15 and emerging biosensing technologies for a future application to CD. Even if biosensing 16 technologies still require further research efforts to develop portable systems, we arrive to the 17 conclusion that biosensors could improve diagnosis and the patients' treatment follow-up, in terms 18 of rapidity, small sample volume, high integration, ease of use, real-time and low cost detection 19 compared to current conventional technologies. 20
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