Article Dans Une Revue Journal of the American Chemical Society Année : 2018

Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues.

Résumé

Lipid droplets (LDs) are intracellular lipid-rich organelles that regulate the storage of neutral lipids and were recently found to be involved in many physiological processes, metabolic disorders, and diseases including obesity, diabetes, and cancers. Herein we present a family of new fluorogenic merocyanine fluorophores based on an indolenine moiety and a dioxaborine barbiturate derivative. These so-called StatoMerocyanines (SMCy) fluoresce from yellow to the near-infrared (NIR) in oil with an impressive fluorescence enhancement compared to aqueous media. Additionally, SMCy display remarkably high molar extinction coefficients (up to 390 000 M

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hal-02390258 , version 1 (02-12-2019)

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Mayeul Collot, Kyong Tkhe Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, et al.. Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues.. Journal of the American Chemical Society, 2018, 140 (16), ⟨10.1021/jacs.7b12817⟩. ⟨hal-02390258⟩
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