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Article Dans Une Revue Chemical Reviews Année : 2017

Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis

Résumé

Aminoacyl-tRNAs were long thought to be involved solely in ribosome-dependent protein synthesis and essential primary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis. About 10 years ago, an aminoacyl-tRNA-dependent enzyme involved in the biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain. Far from being an isolated case, this discovery has been followed by the description of an increasing number of aminoacyl-tRNA-dependent enzymes involved in secondary metabolism. This review describes the three groups of aminoacyl-tRNA-dependent enzymes involved in the synthesis of natural products. Each group is characterized by a particular chemical reaction, and its members are predicted to share a specific fold. The three groups are cyclodipeptide synthases involved in diketopiperazine synthesis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, and transferases from various biosynthesis pathways.
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Dates et versions

hal-02390033 , version 1 (02-12-2019)

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Mireille Moutiez, Pascal Belin, Muriel Gondry. Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis. Chemical Reviews, 2017, ⟨10.1021/acs.chemrev.6b00523⟩. ⟨hal-02390033⟩
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