In this paper, we propose a conceptual framework for classifying operations management-related issues for returnable transport items (RTI). RTI closed-loop supply chain (CLSC) issues are classified into three categories. Our proposal is based on a global literature review in the field of CLSC and reverse logistics (RL), with a specific focus on transport items reuse. We also derive our work from observations made in the automotive industry. The motivation for dealing with this topic is that more and more companies are adopting RTIs in their supply chain, and despite the growing attention that CLSC and RL research have gained during the last years, the focus is still more oriented toward remanufacturing issues. The objectives of this paper are twofold. Firstly, to provide practitioners with a clear vision on different issues that arise when implementing a RTI system from an operations management point of view, and secondly, to give suggestions to researchers regarding existing gaps that still need to be filled in this field.