Correlation between cardio-pulmonary exercise test variables and ă health-related quality of life among children with congenital heart ă diseases - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Cardiology Année : 2016

Correlation between cardio-pulmonary exercise test variables and ă health-related quality of life among children with congenital heart ă diseases

S. Moniotte
  • Fonction : Auteur
R. Dorka
  • Fonction : Auteur
H. Bertet
  • Fonction : Auteur

Résumé

Background: Health-related quality of life (HR-QoL) stands as a ă determinant ``patient-related outcome'' and correlates with ă cardio-pulmonary exercise test (CPET) in adults with chronic heart ă failure or with a congenital heart disease (CHD). No such correlation ă has been established in pediatric cardiology. ă Methods and results: 202 CHD children aged 8 to 18 performed a CPET ă (treadmill n = 96, cycle-ergometer n = 106). CHD severity was stratified ă into 4 groups. All children and parents filled out the Kidscreen HR-QoL ă questionnaire. Peak VO2, anaerobic threshold (AT), and oxygen pulse ă followed a downward significant trend with increasing CHD severity and ă conversely for VE/VCO2 slope. Self-reported and parent-reported physical ă well-being HR-QoL scores correlated with peak VO2 (respectively r = ă 0.27, p < 0.0001 and r = 0.43, p < 0.0001), percentage of predicted peak ă VO2 (r = 0.28, p = 0.0001 and r = 0.41, p < 0.0001), and percentage of ă predicted VO2 at AT (r = 0.22, p < 0.01 and r = 0.31, p < 0.0001). ă Significant correlations were also observed between several HR-QoL ă dimensions and dead space to tidal volume ratio (VD/VT), oxygen uptake ă efficiency slope (OUES), oxygen pulse but never with VE/VCO2 slope. The ă strongest correlations were observed in the treadmill group, especially ă between peak VO2 and physical well-being for parents (r = 0.57, p < ă 0.0001) and self (r = 0.40, p < 0.0001) reported HR-QoL. ă Conclusions: Peak VO2 and AT are the two CPET variables that best ă correlated with HR-QoL in this large pediatric cohort, parents' reports ă being more accurate. If HR-QoL is involved as a ``PRO'' in a pediatric ă cardiology clinical trial, we suggest using parents related physical ă well-being HR-QoL scores. (C) 2015 Elsevier Ireland Ltd. All rights ă reserved.
Fichier principal
Vignette du fichier
2016 Amedro 2.pdf (753.34 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02383830 , version 1 (28-11-2019)

Identifiants

Citer

P. Amedro, M. C. Picot, S. Moniotte, R. Dorka, H. Bertet, et al.. Correlation between cardio-pulmonary exercise test variables and ă health-related quality of life among children with congenital heart ă diseases. International Journal of Cardiology, 2016, 203, pp.1052-1060. ⟨10.1016/j.ijcard.2015.11.028⟩. ⟨hal-02383830⟩
145 Consultations
342 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More