Effects of road traffic on climate change and health are now well established. As mobility needs are constantly increasing, policy decision-makers are looking for solutions to reduce greenhouse gases and pollutant emissions in large cities. Various traffic management measures can be considered. One of the possible strategies is based on changing users' departure time. Indeed, spreading users over time can potentially calm traffic, reduce peak congestion and related emissions. This initial analysis showed that changing the departure time can lead to improved network performance and reduced modestly related emissions. The proposed approach is based on MFD simulation, which allows a large number of simulations to be performed in a reasonable time.