Fighting hypoxia to improve PDT - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Pharmaceuticals Année : 2019

Fighting hypoxia to improve PDT

Résumé

Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: (1) The use of O2 vehicle; (2) the modification of the tumour microenvironment (TME); (3) combining other therapies with PDT; (4) hypoxia-independent PDT; (5) hypoxia-dependent PDT and (6) fractional PDT.

Mots clés

Domaines

Cancer Chimie
Fichier principal
Vignette du fichier
pharmaceuticals-12-00163-v2.pdf (18.45 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02381124 , version 1 (23-01-2024)

Identifiants

Citer

Ludivine Larue, Bauyrzhan Myrzakhmetov, Amina Ben-Mihoub, Albert Moussaron, Noémie Thomas, et al.. Fighting hypoxia to improve PDT. Pharmaceuticals, 2019, 12 (4), pp.163. ⟨10.3390/ph12040163⟩. ⟨hal-02381124⟩
114 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More