Catalysis by triflic acid : synthesis of the indolyquinones as potential antitumor agent
Résumé
Trifluoromethanesulfonic acid catalyzes efficiently the conjugate addition of indoles to p-benzoquinones under mild conditions affording the corresponding indolylquinones in high yields with high selectivity.
In particular the poorly reactive menadione underwent reaction with indoles under similar conditions to give 3-indolylnaphthoquinones
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