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Article Dans Une Revue RSC Advances Année : 2019

Chitosan/hydroxyapatite modified carbon/carbon composites: synthesis, characterization and in vitro biocompatibility evaluation

Wenbo Wang
  • Fonction : Auteur
Ning Cao
  • Fonction : Auteur
Jianwen Dong
  • Fonction : Auteur
Wei Liu
Yujie Li
  • Fonction : Auteur
Haibo Cong
  • Fonction : Auteur

Résumé

Carbon/carbon composite (C/C), due to its bio-inert property, is prone to cause bone consolidation defects and bacterial infections in clinical applications. Therefore, there is a great demand in practical applications to prevent implant infections and enhance its bone consolidation capability. In this study, we have developed a facile approach to construct a chitosan/hydroxyapatite composite modified layer on C/C surface by electrochemical deposition and a covalent grafting technique, and the modified layer has both the antibacterial activity of chitosan (CS) and the bioactivity of hydroxyapatite (HAP). The microstructure and chemical composition of the modified layer were analyzed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The biological properties of the composites were evaluated using cell culture, antimicrobial test and real-time quantitative PCR in vitro. The results showed that the CS/HAP modified C/C exhibited excellent biocompatibility, bacteriostasis and osteoinductive ability. These properties are beneficial for the potential application of the modified C/C composite as a bone tissue replacement material.

Domaines

Chimie Matériaux
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Dates et versions

hal-02373150 , version 1 (23-05-2022)

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Paternité - Pas d'utilisation commerciale

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Wenbo Wang, Ning Cao, Jianwen Dong, Rabah Boukherroub, Wei Liu, et al.. Chitosan/hydroxyapatite modified carbon/carbon composites: synthesis, characterization and in vitro biocompatibility evaluation. RSC Advances, 2019, 9 (40), pp.23362-23372. ⟨10.1039/c8ra10396h⟩. ⟨hal-02373150⟩
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