Ruminococcin C, a promising antibiotic produced by a human gut symbiont - Archive ouverte HAL Access content directly
Journal Articles Science Advances Year : 2019

Ruminococcin C, a promising antibiotic produced by a human gut symbiont

Steve Chiumento
  • Function : Author
Chloé Leprêtre
  • Function : Author
Christian Basset
  • Function : Author
Dwi Aditiyarini
  • Function : Author
Olga Iranzo
Marc Maresca
Yohann Couté
Mohamed Atta
  • Function : Author
  • PersonId : 859484
Victor Duarte
  • Function : Correspondent author
  • PersonId : 860137

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A major public health challenge today is the resurgence of microbial infections caused by multidrug-resistant strains. Consequently, novel antimicrobial molecules are actively sought for development. In this context, the human gut microbiome is an under-explored potential trove of valuable natural molecules, such as the ribosomally-synthesized and post-translationally modified peptides (RiPPs). The biological activity of the sactipeptide subclass of RiPPs remains under-characterized. Here, we characterize an antimicrobial sactipeptide, Ruminococcin C1, purified from the caecal contents of rats mono-associated with Ruminococcus gnavus E1, a human symbiont. Its heterologous expression and post-translational maturation involving a specific sactisynthase establish a thioether network, which creates a double-hairpin folding. This original structure confers activity against pathogenic Clostridia and multidrug-resistant strains but no toxicity towards eukaryotic cells. Therefore, the Ruminococcin C1 should be considered as a valuable candidate for drug development and its producer strain R. gnavus E1 as a relevant probiotic for gut health enhancement.
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hal-02371747 , version 1 (20-11-2019)



Steve Chiumento, Clarisse Roblin, Sylvie Kieffer-Jaquinod, Sybille Tachon, Chloé Leprêtre, et al.. Ruminococcin C, a promising antibiotic produced by a human gut symbiont. Science Advances , 2019, 5 (9), pp.eaaw9969. ⟨10.1126/sciadv.aaw9969⟩. ⟨hal-02371747⟩
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