TAFA4, a Chemokine-like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2013

TAFA4, a Chemokine-like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice

Amaury François
Emmanuel Bourinet
Patrick Delmas
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Résumé

C-low-threshold mechanoreceptors (C-LTMRs) are unique among C-unmyelinated primary sensory neu-rons. These neurons convey two opposite aspects of touch sensation: a sensation of pleasantness, and a sensation of injury-induced mechanical pain. Here, we show that TAFA4 is a specific marker of C-LTMRs. Genetic labeling in combination with electrophy-siological recordings show that TAFA4+ neurons have intrinsic properties of mechano-nociceptors. TAFA4-null mice exhibit enhanced mechanical and chemical hypersensitivity following inflammation and nerve injury as well as increased excitability of spinal cord lamina IIi neurons, which could be reversed by intrathecal or bath application of recom-binant TAFA4 protein. In wild-type C57/Bl6 mice, intrathecal administration of TAFA4 strongly reversed carrageenan-induced mechanical hypersensitivity, suggesting a potent analgesic role of TAFA4 in pain relief. Our data provide insights into how C-LTMR-derived TAFA4 modulates neuronal excitability and controls the threshold of somatic sensation.

Domaines

Neurobiologie
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Dates et versions

hal-02370525 , version 1 (19-11-2019)

Identifiants

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Marie-Claire Delfini, Annabelle Mantilleri, Stéphane Gaillard, Jizhe Hao, Ana Reynders, et al.. TAFA4, a Chemokine-like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice. Cell Reports, 2013, 5 (2), pp.378-388. ⟨10.1016/j.celrep.2013.09.013⟩. ⟨hal-02370525⟩
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