Elaboration of Sterically Hindered δ-Lactones through Ring-Closing Metathesis: Application to the Synthesis of the C1–C27 Fragment of Hemicalide - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2016

Elaboration of Sterically Hindered δ-Lactones through Ring-Closing Metathesis: Application to the Synthesis of the C1–C27 Fragment of Hemicalide

Résumé

The synthesis of the C1–C27 fragment of hemicalide, a marine metabolite displaying a unique potent antiproliferative activity, has been accomplished. The synthetic approach highlights a remarkably efficient ring-closing metathesis reaction catalyzed by Nolan ruthenium indenylidene complexes to elaborate the highly substituted δ-lactone framework.

Domaines

Chimie organique
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Dates et versions

hal-02370458 , version 1 (05-10-2021)

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Camille Lecourt, Srikanth Boinapally, Sabrina Dhambri, Guillaume Boissonnat, Christophe Meyer, et al.. Elaboration of Sterically Hindered δ-Lactones through Ring-Closing Metathesis: Application to the Synthesis of the C1–C27 Fragment of Hemicalide. Journal of Organic Chemistry, 2016, 81 (24), pp.12275-12290. ⟨10.1021/acs.joc.6b02208⟩. ⟨hal-02370458⟩
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