Newborn Neurons in the Olfactory Bulb Selected for Long-Term Survival through Olfactory Learning Are Prematurely Suppressed When the Olfactory Memory Is Erased
Résumé
A role for newborn neurons in olfactory memory has been proposed based on learning-dependent modulation of olfactory bulb neuro-genesis in adults. We hypothesized that if newborn neurons support memory, then they should be suppressed by memory erasure. Using an ecological approach in mice, we showed that behaviorally breaking a previously learned odor-reward association prematurely suppressed newborn neurons selected to survive during initial learning. Furthermore, intrabulbar infusions of the caspase pan-inhibitor ZVAD (benzyloxycarbonyl-Val-Ala-Asp) during the behavioral odor-reward extinction prevented newborn neurons death and erasure of the odor-reward association. Newborn neurons thus contribute to the bulbar network plasticity underlying long-term memory.
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