The system‐centered informal representation of a local reality is originally built intentionally by a “sentient being” who is aware that a real situation requires a certain wholeness. The work is based on a pragmatic body of interdisciplinary knowledge constitutive of a system‐centered architecting specification, in harmony with human‐centered and technical‐centered multidisciplinary knowledge. It is necessary to inquire about its outwards materiality as an integrative foundation of multidisciplinary systems engineering, respectively technical and human‐centered. Formalizing the physico‐physiological interaction under investigation combines certain elements of multidisciplinary knowledge of integrative physiology. The chapter describes what enables the tangibility of the togetherness of the sensory perception interaction between an “artifact‐source” of an alarm and a “human‐sink” of control, as a necessary condition. The model of human‐centered intelligent measurement is orchestrated in silico in a first step by the system architect throughout the co‐simulation bus for partial system validation.