Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
Merel Postema
,
Daan D van Rooij
(1)
,
Evdokia Anagnostou
(2)
,
Celso Arango
(3)
,
Guillaume M Auzias
(4)
,
Marlene Behrmann
,
Geraldo Busatto Filho
,
Sara Calderoni
,
Rosa Calvo
(5)
,
Eileen Daly
,
Christine Deruelle
(4)
,
Adriana Di Martino
(6)
,
Ilan Dinstein
,
Fabio Luis S. Duran
,
Sarah Durston
(7)
,
Christine Ecker
(8)
,
Stefan Ehrlich
(9)
,
Damien A Fair
(10)
,
Jennifer Fedor
,
Xin Feng
,
Jackie Fitzgerald
,
Dorothea Floris
,
Christine M. Freitag
(11)
,
Louise Gallagher
(12)
,
David D Glahn
(13)
,
Ilaria Gori
,
Shlomi Haar
,
Liesbeth Hoekstra
,
Neda M Jahanshad
(14)
,
Maria Jalbrzikowski
,
Joost Janssen
,
Joseph King
,
Xiang Zhen Kong
,
Luisa Lazaro
,
Jason P Lerch
(15)
,
Beatriz Luna
(16)
,
Mauricio Martinho
,
Jane Mcgrath
(12)
,
Sarah Medland
(17)
,
Filippo Muratori
(18)
,
Clodagh Murphy
,
Declan G. Murphy
(8)
,
Kirsten O’hearn
(19)
,
Bob Oranje
(7)
,
Mara Parellada
(3)
,
Olga Puig
,
Alessandra Retico
,
Pedro Rosa
(20)
,
Katya Rubia
(21)
,
Devon Shook
,
Margot Taylor
,
Michela Tosetti
(22)
,
Gregory Wallace
(23)
,
Fengfeng Zhou
,
Paul Thompson
(24)
,
Simon Fisher
(25)
,
Jan Buitelaar
(26)
,
Clyde Francks
(27)
1
Donders Center for Cognitive Neuroimaging
2 University of Toronto
3 Psychiatry Department, Adolescent Unit
4 INT - Institut de Neurosciences de la Timone
5 Department of Child and Adolescent Psychiatry and Psychology, Centro de Investigación Biomédica en Red de Salut Mental (CIBER-SAM Network)
6 NYU Langone Medical Center
7 UMCU - University Medical Center [Utrecht]
8 Institute of Psychiatry, Psychology & Neuroscience, King's College London
9 MetaGenoPolis
10 OHSU - Oregon Health and Science University [Portland]
11 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
12 Division of Mental Health and Addiction
13 Dpt of Psychiatry [New Haven]
14 David Geffen School of Medicine [Los Angeles]
15 SickKids - The Hospital for sick children [Toronto]
16 IF - Instituto de Fisica
17 Medstar Research Institute
18 IRCCS Fondazione Stella Maris [Pisa]
19 University of Pittsburgh School of Medicine
20 IST / Técnico Lisboa - Instituto Superior Técnico
21 Child Psychiatry
22 Stella Maris
23 UWO - University of Western Ontario
24 LONI - Laboratory of Neuro Imaging [Los Angeles]
25 Max Planck Institute for Psycholinguistics
26 Department of Psychiatry
27 Language and Genetics Department [Nijmegen]
2 University of Toronto
3 Psychiatry Department, Adolescent Unit
4 INT - Institut de Neurosciences de la Timone
5 Department of Child and Adolescent Psychiatry and Psychology, Centro de Investigación Biomédica en Red de Salut Mental (CIBER-SAM Network)
6 NYU Langone Medical Center
7 UMCU - University Medical Center [Utrecht]
8 Institute of Psychiatry, Psychology & Neuroscience, King's College London
9 MetaGenoPolis
10 OHSU - Oregon Health and Science University [Portland]
11 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
12 Division of Mental Health and Addiction
13 Dpt of Psychiatry [New Haven]
14 David Geffen School of Medicine [Los Angeles]
15 SickKids - The Hospital for sick children [Toronto]
16 IF - Instituto de Fisica
17 Medstar Research Institute
18 IRCCS Fondazione Stella Maris [Pisa]
19 University of Pittsburgh School of Medicine
20 IST / Técnico Lisboa - Instituto Superior Técnico
21 Child Psychiatry
22 Stella Maris
23 UWO - University of Western Ontario
24 LONI - Laboratory of Neuro Imaging [Los Angeles]
25 Max Planck Institute for Psycholinguistics
26 Department of Psychiatry
27 Language and Genetics Department [Nijmegen]
Merel Postema
- Fonction : Auteur
Guillaume M Auzias
- Fonction : Auteur
- PersonId : 19274
- IdHAL : guillaume-auzias
- ORCID : 0000-0002-0414-5691
- IdRef : 142544736
Marlene Behrmann
- Fonction : Auteur
Geraldo Busatto Filho
- Fonction : Auteur
Sara Calderoni
- Fonction : Auteur
Eileen Daly
- Fonction : Auteur
Christine Deruelle
- Fonction : Auteur
- PersonId : 12361
- IdHAL : christine-deruelle
- ORCID : 0000-0002-9004-2452
- IdRef : 081774915
Ilan Dinstein
- Fonction : Auteur
Fabio Luis S. Duran
- Fonction : Auteur
Jennifer Fedor
- Fonction : Auteur
Xin Feng
- Fonction : Auteur
Jackie Fitzgerald
- Fonction : Auteur
Dorothea Floris
- Fonction : Auteur
Ilaria Gori
- Fonction : Auteur
Shlomi Haar
- Fonction : Auteur
Liesbeth Hoekstra
- Fonction : Auteur
Maria Jalbrzikowski
- Fonction : Auteur
Joost Janssen
- Fonction : Auteur
Joseph King
- Fonction : Auteur
Xiang Zhen Kong
- Fonction : Auteur
Luisa Lazaro
- Fonction : Auteur
Mauricio Martinho
- Fonction : Auteur
Clodagh Murphy
- Fonction : Auteur
Olga Puig
- Fonction : Auteur
Alessandra Retico
- Fonction : Auteur
Devon Shook
- Fonction : Auteur
Margot Taylor
- Fonction : Auteur
Fengfeng Zhou
- Fonction : Auteur
Résumé
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
Domaines
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