Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2019

How a well-adapting immune system remembers

Résumé

An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a midlife plateau to the ease of learning salient features of sparse environments. We also derive a modulated memory pool update rule in agreement with current vaccine-response experiments. Our results suggest that pathogenic environments are sparse and that memory repertoires significantly decrease infection costs, even with moderate sampling. The predicted optimal update scheme maps onto commonly considered competitive dynamics for antigen receptors.

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hal-02360266 , version 1 (25-11-2024)

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Andreas Mayer, Vijay Balasubramanian, Aleksandra M. Walczak, Thierry Mora. How a well-adapting immune system remembers. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (18), pp.8815-8823. ⟨10.1073/pnas.1812810116⟩. ⟨hal-02360266⟩
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