<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02359573</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T04:48:41+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Hybrid dose calculation algorithm for high flux synchroton X-Rays Microbeam Radiation Therapy (MRT)</title>
            <author role="aut">
              <persName>
                <forename type="first">Sarvenaz</forename>
                <surname>Keshmiri</surname>
              </persName>
              <idno type="halauthorid">1705722-0</idno>
              <affiliation ref="#struct-3005"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Ocadiz</surname>
              </persName>
              <email type="md5">7997f17df362c45a5b732ddd593c6fa1</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">alexandre-ocadiz</idno>
              <idno type="idhal" notation="numeric">736883</idno>
              <idno type="halauthorid" notation="string">44621-736883</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9350-5352</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?hl=fr&amp;user=ldzfn9EAAAAJ</idno>
              <affiliation ref="#struct-3005"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphaël</forename>
                <surname>Serduc</surname>
              </persName>
              <email type="md5">1cd83e77d35ed32d6d27eab40180c633</email>
              <email type="domain">esrf.fr</email>
              <idno type="idhal" notation="numeric">860087</idno>
              <idno type="halauthorid" notation="string">391470-860087</idno>
              <affiliation ref="#struct-3005"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Adam</surname>
              </persName>
              <email type="md5">60f8474e283db70fb6bdfc0c94028158</email>
              <email type="domain">esrf.fr</email>
              <idno type="idhal" notation="numeric">900104</idno>
              <idno type="halauthorid" notation="string">391510-900104</idno>
              <affiliation ref="#struct-3005"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Béatrice</forename>
                <surname>Rayet</surname>
              </persName>
              <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
              <email type="domain">creatis.insa-lyon.fr</email>
            </editor>
            <funder ref="#projanr-49807"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-11-12 14:31:01</date>
              <date type="whenModified">2025-10-16 09:21:05</date>
              <date type="whenReleased">2019-11-12 14:31:01</date>
              <date type="whenProduced">2019-11-20</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="180336">
                <persName>
                  <forename>Béatrice</forename>
                  <surname>Rayet</surname>
                </persName>
                <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
                <email type="domain">creatis.insa-lyon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02359573</idno>
            <idno type="halUri">https://hal.science/hal-02359573</idno>
            <idno type="halBibtex">keshmiri:hal-02359573</idno>
            <idno type="halRefHtml">&lt;i&gt;Journées Mi2B/SFPM 2019&lt;/i&gt;, Nov 2019, Nantes, France</idno>
            <idno type="halRef">Journées Mi2B/SFPM 2019, Nov 2019, Nantes, France</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno>
            <idno type="stamp" n="PRIMES_WP3" corresp="PRIMES">WP3: Radiobiologie, instrumentation et modèles pour une thérapie innovante</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ESRF"> European Synchrotron Radiation Facility</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Hybrid dose calculation algorithm for high flux synchroton X-Rays Microbeam Radiation Therapy (MRT)</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Sarvenaz</forename>
                    <surname>Keshmiri</surname>
                  </persName>
                  <idno type="halauthorid">1705722-0</idno>
                  <affiliation ref="#struct-3005"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Ocadiz</surname>
                  </persName>
                  <email type="md5">7997f17df362c45a5b732ddd593c6fa1</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">alexandre-ocadiz</idno>
                  <idno type="idhal" notation="numeric">736883</idno>
                  <idno type="halauthorid" notation="string">44621-736883</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9350-5352</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?hl=fr&amp;user=ldzfn9EAAAAJ</idno>
                  <affiliation ref="#struct-3005"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphaël</forename>
                    <surname>Serduc</surname>
                  </persName>
                  <email type="md5">1cd83e77d35ed32d6d27eab40180c633</email>
                  <email type="domain">esrf.fr</email>
                  <idno type="idhal" notation="numeric">860087</idno>
                  <idno type="halauthorid" notation="string">391470-860087</idno>
                  <affiliation ref="#struct-3005"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Adam</surname>
                  </persName>
                  <email type="md5">60f8474e283db70fb6bdfc0c94028158</email>
                  <email type="domain">esrf.fr</email>
                  <idno type="idhal" notation="numeric">900104</idno>
                  <idno type="halauthorid" notation="string">391510-900104</idno>
                  <affiliation ref="#struct-3005"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>Journées Mi2B/SFPM 2019</title>
                  <date type="start">2019-11-20</date>
                  <date type="end">2019-11-22</date>
                  <settlement>Nantes</settlement>
                  <country key="FR">France</country>
                </meeting>
                <imprint/>
              </monogr>
              <ref type="publisher">https://indico.in2p3.fr/event/19281/overview</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="phys.phys.phys-med-ph">Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Sarvenaz KESHMIRI, Alexandre Ocadiz, Raphaël Serduc, Jean-François AdamInserm UA7, Université Grenoble Alpes, STROBE, Grenoble, FranceAbstractA curative radiation therapy treatment requires high absorbed dose in a malignant area and minimizing the damages to the neighbouring normal tissues. Increased normal tissue sparing effect to highly spatially fractionated radiation therapy (SFRT) has been extensively explored for the past 25 years. Microbeam radiation therapy (MRT) is an approach based on dose-volume effect which uses spatially fractionated high flux synchrotron X-ray beams as arrays of micrometric beamlets. The zone of interest is irradiated with high doses through beams path (&gt;100 Gy) and doses below tolerance level between the beamlets. The precilinical experiences performed at the European Synchrotron Radiation Facility (ESRF) confirmed the MRT’s higher therapeutic index compared to non-fractionated beams with the same characteristics.The biological response and in consequence the effectiveness of MRT treatments depend on beamlet dose (peak) and central dose between beamlets (valley) as well as peak to valley dose ratio (PVDR). In order to have an optimal therapeutic gain, the PVDR should be maximised and accurately calculated. The commercially available treatment planning systems (TPS) are not suitable for MRT dose planning, due to its distinct features of irradiation geometry, beam source, low energy spectrum and beam polarization compared to conventionalradiotherapy. Therefore, in pursuing the realisation of this treatment modality, it is important to have a modern treatment planning paradigm. There are three categories of dose calculation methods for MRT: pure Monte Carlo, convolution based methods and hybrid methods. The aims of this study was to investigate the reliability, the pros and cons of hybrid dose calculation algorithm and to validate this algorithm using experimental film dosimetry</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-3005" status="INCOMING">
          <orgName>Rayonnement Synchrotron et Recherche Medicale</orgName>
          <orgName type="acronym">RSRM</orgName>
          <desc>
            <address>
              <addrLine>6, Rue Jules Horowitz 38043 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.esrf.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-2568" type="direct"/>
            <relation active="#struct-51016" type="direct"/>
            <relation name="U647" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-2568" status="OLD">
          <idno type="ROR">https://ror.org/02550n020</idno>
          <orgName>European Synchrotron Radiation Facility</orgName>
          <orgName type="acronym">ESRF</orgName>
          <date type="start">1988-01-01</date>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>6 rue Jules Horowitz BP220 38043 GRENOBLE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.esrf.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-49807" status="VALID">
          <idno type="anr">ANR-11-LABX-0063</idno>
          <orgName>PRIMES</orgName>
          <desc>Physique, Radiobiologie, Imagerie Médicale et Simulation</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>