Journal Articles Clinical Lymphoma, Myeloma & Leukemia Year : 2012

Ten-Year Relative Survival and Causes of Death in Elderly Patients Treated With R-CHOP or CHOP in the GELA LNH-985 Trial

Abstract

Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of oxygen, is named the Warburg effect. Because cancer cells are partly or mainly dependent on such a pathway to generate ATP, inhibition of glycolysis may slow down the proliferation or kill cells.

Dates and versions

hal-02358962 , version 1 (12-11-2019)

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Nicolas Mounier, Natacha Heutte, Catherine Thiéblemont, Josette Brière, Philippe Gaulard, et al.. Ten-Year Relative Survival and Causes of Death in Elderly Patients Treated With R-CHOP or CHOP in the GELA LNH-985 Trial. Clinical Lymphoma, Myeloma & Leukemia, 2012, 12 (3), pp.151-154. ⟨10.1016/j.clml.2011.11.004⟩. ⟨hal-02358962⟩
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