Long-Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart

We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells.

Mots clés

Myoblasts Heart failure Clinical cell transplantation Long-term follow-up Myoblasts

Domaines

Cardiologie et système cardiovasculaire Anatomie, Histologie, Anatomopathologie [q-bio.TO]

Fichier principal

Crahes Stem Cells Translational Medicine 2018.pdf (11.44 Mo)

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Jean-Thomas Vilquin : Connectez-vous pour contacter le contributeur

https://hal.science/hal-02356366

Soumis le : vendredi 8 novembre 2019-16:53:12

Dernière modification le : samedi 16 novembre 2024-03:32:16

Archivage à long terme le : lundi 10 février 2020-12:19:12

Dates et versions

hal-02356366 , version 1 (08-11-2019)

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Paternité

Identifiants

HAL Id : hal-02356366 , version 1
DOI : 10.1002/sctm.18-0017

Citer

Marie Crahes, Marie-Cécile Bories, Jean-Thomas Vilquin, Jean-Pierre Marolleau, Michel Desnos, et al.. Long-Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart. Stem Cells Translational Medicine, 2018, 7 (10), pp.705 - 708. ⟨10.1002/sctm.18-0017⟩. ⟨hal-02356366⟩

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