<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02355962</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T13:27:59+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Porphyrin‐based bridged silsesquioxane nanoparticles for targeted two‐photon photodynamic therapy of zebrafish xenografted with human tumor</title>
            <author role="aut">
              <persName>
                <forename type="first">Soraya</forename>
                <surname>Dib</surname>
              </persName>
              <idno type="halauthorid">1707225-0</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dina</forename>
                <surname>Aggad</surname>
              </persName>
              <email type="md5">35c5542d634e8623c0977be489fd5af1</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">aggad-d</idno>
              <idno type="idhal" notation="numeric">1553277</idno>
              <idno type="halauthorid" notation="string">1053241-1553277</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4212-4197</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chiara</forename>
                <surname>Mauriello Jimenez</surname>
              </persName>
              <idno type="halauthorid">1248817-0</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ahmed</forename>
                <surname>Lakrafi</surname>
              </persName>
              <idno type="halauthorid">1707226-0</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Héry</surname>
              </persName>
              <idno type="halauthorid">909892-0</idno>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Nguyen</surname>
              </persName>
              <email type="md5">ad9c1783f67ebe10a1bb9857b9c89344</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">christophe-nguyen-34</idno>
              <idno type="idhal" notation="numeric">1268290</idno>
              <idno type="halauthorid" notation="string">53585-1268290</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4539-1677</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Denis</forename>
                <surname>Durand</surname>
              </persName>
              <idno type="halauthorid">854888-0</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Morère</surname>
              </persName>
              <email type="md5">bca1b0a8aacd7eefb5a4d7223b6342c9</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">alain-morere</idno>
              <idno type="idhal" notation="numeric">1019435</idno>
              <idno type="halauthorid" notation="string">190253-1019435</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3269-5172</idno>
              <idno type="IDREF">https://www.idref.fr/068774591</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Khaled</forename>
                <surname>El Cheikh</surname>
              </persName>
              <idno type="halauthorid">190292-0</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Sol</surname>
              </persName>
              <email type="md5">4adb499d0bdd1e5f88492c0e5d6527a8</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="string">vincent-sol</idno>
              <idno type="idhal" notation="numeric">182804</idno>
              <idno type="halauthorid" notation="string">12793-182804</idno>
              <idno type="IDREF">https://www.idref.fr/144796872</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0175-0156</idno>
              <idno type="VIAF">https://viaf.org/viaf/215296279</idno>
              <idno type="ISNI">http://isni.org/isni/0000000432514209</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=57mHHF8AAAAJ&amp;hl=fr</idno>
              <affiliation ref="#struct-635"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Chaleix</surname>
              </persName>
              <email type="md5">445c60d0b3bf6d2de086ccbe741baa7f</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">761711</idno>
              <idno type="halauthorid" notation="string">415340-761711</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5324-3095</idno>
              <idno type="IDREF">https://www.idref.fr/07690413X</idno>
              <idno type="VIAF">https://viaf.org/viaf/216124990</idno>
              <idno type="ISNI">http://isni.org/isni/0000000359046284</idno>
              <affiliation ref="#struct-635"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sofia</forename>
                <surname>Dominguez Gil</surname>
              </persName>
              <idno type="halauthorid">1671149-0</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Bouchmella</surname>
              </persName>
              <email type="md5">52b0ab11a5684d1e83d8365cd88f536f</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">karim-bouchmella</idno>
              <idno type="idhal" notation="numeric">825084</idno>
              <idno type="halauthorid" notation="string">244230-825084</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8660-802X</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Raehm</surname>
              </persName>
              <email type="md5">603895de3824c4488763406c57ca25f3</email>
              <email type="domain">univ-montp2.fr</email>
              <idno type="idhal" notation="numeric">1275331</idno>
              <idno type="halauthorid" notation="string">238040-1275331</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6300-1279</idno>
              <idno type="IDREF">https://www.idref.fr/194653226</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean‐olivier</forename>
                <surname>Durand</surname>
              </persName>
              <idno type="halauthorid">1699323-0</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Makhlouf</forename>
                <surname>Boufatit</surname>
              </persName>
              <idno type="halauthorid">862180-0</idno>
              <affiliation ref="#struct-92874"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Cattoën</surname>
              </persName>
              <email type="md5">d254ed876a06d35516eaeeb5a0fa2235</email>
              <email type="domain">neel.cnrs.fr</email>
              <idno type="idhal" notation="string">xavier-cattoen</idno>
              <idno type="idhal" notation="numeric">184645</idno>
              <idno type="halauthorid" notation="string">727447-184645</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1072-0573</idno>
              <idno type="IDREF">https://www.idref.fr/083022295</idno>
              <idno type="VIAF">https://viaf.org/viaf/190658540</idno>
              <idno type="ISNI">http://isni.org/isni/0000000356517917</idno>
              <affiliation ref="#struct-1042414"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Wong Chi Man</surname>
              </persName>
              <email type="md5">5a2c4661864b5a1b64e89caf7376f233</email>
              <email type="domain">enscm.fr</email>
              <idno type="idhal" notation="numeric">1445725</idno>
              <idno type="halauthorid" notation="string">218711-1445725</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1390-4239</idno>
              <affiliation ref="#struct-1087107"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadir</forename>
                <surname>Bettache</surname>
              </persName>
              <email type="md5">b68449b37cf89bdb7d90df04019bdd50</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">nadir-bettache</idno>
              <idno type="idhal" notation="numeric">742291</idno>
              <idno type="halauthorid" notation="string">52254-742291</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5426-7024</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Magali</forename>
                <surname>Gary‐bobo</surname>
              </persName>
              <email type="md5">65beb22fd74fcfab7f4cadd934d89551</email>
              <email type="domain">valdorel.fnclcc.fr</email>
              <idno type="idhal" notation="string">magali-gary-bobo</idno>
              <idno type="idhal" notation="numeric">950459</idno>
              <idno type="halauthorid" notation="string">1699322-950459</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9641-212X</idno>
              <idno type="IDREF">https://www.idref.fr/099855267</idno>
              <affiliation ref="#struct-24488"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean-Olivier</forename>
                <surname>Durand</surname>
              </persName>
              <email type="md5">0b2d4c2f718c9e066e3d8124e462016b</email>
              <email type="domain">univ-montp2.fr.invalid</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-12-15 15:36:19</date>
              <date type="whenModified">2025-09-27 18:57:41</date>
              <date type="whenReleased">2020-12-16 13:42:18</date>
              <date type="whenProduced">2019</date>
              <date type="whenEndEmbargoed">2020-12-08</date>
              <ref type="file" target="https://hal.science/hal-02355962v1/document">
                <date notBefore="2020-12-08"/>
              </ref>
              <ref type="file" subtype="publisherAgreement" n="1" target="https://hal.science/hal-02355962v1/file/Dib_et_al-2019-Cancer_Reports.pdf" id="file-3026083-2693401">
                <date notBefore="2020-12-08"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-02355962/file/Dib_et_al-2019-Cancer_Reports.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="122005">
                <persName>
                  <forename>Jean-Olivier</forename>
                  <surname>Durand</surname>
                </persName>
                <email type="md5">0b2d4c2f718c9e066e3d8124e462016b</email>
                <email type="domain">univ-montp2.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02355962</idno>
            <idno type="halUri">https://hal.science/hal-02355962</idno>
            <idno type="halBibtex">dib:hal-02355962</idno>
            <idno type="halRefHtml">&lt;i&gt;Cancer reports&lt;/i&gt;, 2019, 2 (5), pp.e1186. &lt;a target="_blank" href="https://dx.doi.org/10.1002/cnr2.1186"&gt;&amp;#x27E8;10.1002/cnr2.1186&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cancer reports, 2019, 2 (5), pp.e1186. &amp;#x27E8;10.1002/cnr2.1186&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3026083-2693401"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNILIM">Université de Limoges</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ENSC-MONTPELLIER">Ecole Nationale Supérieure de Chimie de Montpellier</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="NEEL">Institut Néel</idno>
            <idno type="stamp" n="ICG">Institut Charles Gerhardt - Institut de Chimie Moléculaire et des Matériaux de Montpellier</idno>
            <idno type="stamp" n="IBMM">Institut des Biomolécules Max Mousseron</idno>
            <idno type="stamp" n="LCSN" corresp="UNILIM">Laboratoire de Chimie des Substances Naturelles</idno>
            <idno type="stamp" n="GEIST" corresp="UNILIM">Génomique, environnement, immunité, thérapeutique</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="NEEL-OPTIMA">Optique et matériaux</idno>
            <idno type="stamp" n="CHIMIE">Chimie</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="PEIRENE" corresp="UNILIM">PEIRENE</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="OMEGAHEALTH" corresp="UNILIM">OmegaHealth</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="LABCIS" corresp="UNILIM">Laboratoire des Agroressources, Biomolécules et Chimie pour l’Innovation en Santé</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Porphyrin‐based bridged silsesquioxane nanoparticles for targeted two‐photon photodynamic therapy of zebrafish xenografted with human tumor</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Soraya</forename>
                    <surname>Dib</surname>
                  </persName>
                  <idno type="halauthorid">1707225-0</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dina</forename>
                    <surname>Aggad</surname>
                  </persName>
                  <email type="md5">35c5542d634e8623c0977be489fd5af1</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">aggad-d</idno>
                  <idno type="idhal" notation="numeric">1553277</idno>
                  <idno type="halauthorid" notation="string">1053241-1553277</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4212-4197</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chiara</forename>
                    <surname>Mauriello Jimenez</surname>
                  </persName>
                  <idno type="halauthorid">1248817-0</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ahmed</forename>
                    <surname>Lakrafi</surname>
                  </persName>
                  <idno type="halauthorid">1707226-0</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Héry</surname>
                  </persName>
                  <idno type="halauthorid">909892-0</idno>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Nguyen</surname>
                  </persName>
                  <email type="md5">ad9c1783f67ebe10a1bb9857b9c89344</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">christophe-nguyen-34</idno>
                  <idno type="idhal" notation="numeric">1268290</idno>
                  <idno type="halauthorid" notation="string">53585-1268290</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4539-1677</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Denis</forename>
                    <surname>Durand</surname>
                  </persName>
                  <idno type="halauthorid">854888-0</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Morère</surname>
                  </persName>
                  <email type="md5">bca1b0a8aacd7eefb5a4d7223b6342c9</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">alain-morere</idno>
                  <idno type="idhal" notation="numeric">1019435</idno>
                  <idno type="halauthorid" notation="string">190253-1019435</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3269-5172</idno>
                  <idno type="IDREF">https://www.idref.fr/068774591</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Khaled</forename>
                    <surname>El Cheikh</surname>
                  </persName>
                  <idno type="halauthorid">190292-0</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Sol</surname>
                  </persName>
                  <email type="md5">4adb499d0bdd1e5f88492c0e5d6527a8</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="string">vincent-sol</idno>
                  <idno type="idhal" notation="numeric">182804</idno>
                  <idno type="halauthorid" notation="string">12793-182804</idno>
                  <idno type="IDREF">https://www.idref.fr/144796872</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0175-0156</idno>
                  <idno type="VIAF">https://viaf.org/viaf/215296279</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000432514209</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=57mHHF8AAAAJ&amp;hl=fr</idno>
                  <affiliation ref="#struct-635"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Chaleix</surname>
                  </persName>
                  <email type="md5">445c60d0b3bf6d2de086ccbe741baa7f</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">761711</idno>
                  <idno type="halauthorid" notation="string">415340-761711</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5324-3095</idno>
                  <idno type="IDREF">https://www.idref.fr/07690413X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/216124990</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000359046284</idno>
                  <affiliation ref="#struct-635"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sofia</forename>
                    <surname>Dominguez Gil</surname>
                  </persName>
                  <idno type="halauthorid">1671149-0</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Bouchmella</surname>
                  </persName>
                  <email type="md5">52b0ab11a5684d1e83d8365cd88f536f</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">karim-bouchmella</idno>
                  <idno type="idhal" notation="numeric">825084</idno>
                  <idno type="halauthorid" notation="string">244230-825084</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8660-802X</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Raehm</surname>
                  </persName>
                  <email type="md5">603895de3824c4488763406c57ca25f3</email>
                  <email type="domain">univ-montp2.fr</email>
                  <idno type="idhal" notation="numeric">1275331</idno>
                  <idno type="halauthorid" notation="string">238040-1275331</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6300-1279</idno>
                  <idno type="IDREF">https://www.idref.fr/194653226</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean‐olivier</forename>
                    <surname>Durand</surname>
                  </persName>
                  <idno type="halauthorid">1699323-0</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Makhlouf</forename>
                    <surname>Boufatit</surname>
                  </persName>
                  <idno type="halauthorid">862180-0</idno>
                  <affiliation ref="#struct-92874"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Cattoën</surname>
                  </persName>
                  <email type="md5">d254ed876a06d35516eaeeb5a0fa2235</email>
                  <email type="domain">neel.cnrs.fr</email>
                  <idno type="idhal" notation="string">xavier-cattoen</idno>
                  <idno type="idhal" notation="numeric">184645</idno>
                  <idno type="halauthorid" notation="string">727447-184645</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1072-0573</idno>
                  <idno type="IDREF">https://www.idref.fr/083022295</idno>
                  <idno type="VIAF">https://viaf.org/viaf/190658540</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000356517917</idno>
                  <affiliation ref="#struct-1042414"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Wong Chi Man</surname>
                  </persName>
                  <email type="md5">5a2c4661864b5a1b64e89caf7376f233</email>
                  <email type="domain">enscm.fr</email>
                  <idno type="idhal" notation="numeric">1445725</idno>
                  <idno type="halauthorid" notation="string">218711-1445725</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1390-4239</idno>
                  <affiliation ref="#struct-1087107"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadir</forename>
                    <surname>Bettache</surname>
                  </persName>
                  <email type="md5">b68449b37cf89bdb7d90df04019bdd50</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">nadir-bettache</idno>
                  <idno type="idhal" notation="numeric">742291</idno>
                  <idno type="halauthorid" notation="string">52254-742291</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5426-7024</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Magali</forename>
                    <surname>Gary‐bobo</surname>
                  </persName>
                  <email type="md5">65beb22fd74fcfab7f4cadd934d89551</email>
                  <email type="domain">valdorel.fnclcc.fr</email>
                  <idno type="idhal" notation="string">magali-gary-bobo</idno>
                  <idno type="idhal" notation="numeric">950459</idno>
                  <idno type="halauthorid" notation="string">1699322-950459</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9641-212X</idno>
                  <idno type="IDREF">https://www.idref.fr/099855267</idno>
                  <affiliation ref="#struct-24488"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">146300</idno>
                <idno type="eissn">2573-8348</idno>
                <title level="j">Cancer reports</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">2</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">e1186</biblScope>
                  <date type="datePub">2019</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/cnr2.1186</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">photodynamic therapy</term>
                <term xml:lang="en">two-photon excitation</term>
                <term xml:lang="en">human tumor targeting</term>
                <term xml:lang="en">bridged silsesquioxane nanoparticles</term>
              </keywords>
              <classCode scheme="halDomain" n="chim.ther">Chemical Sciences/Medicinal Chemistry</classCode>
              <classCode scheme="halDomain" n="chim.inor">Chemical Sciences/Inorganic chemistry</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: Bridged silsesquioxane nanoparticles (BSNs) recently described represent a new class of nanoparticles exhibiting versatile applications and particularly a strong potential for nanomedicine.Aims: In this work, we describe the synthesis of BSNs from an octasilylated functional porphyrin precursor (PORBSNs) efficiently obtained through a click reaction. These innovative and very small-sized nanoparticles were functionalized with PEG and mannose (PORBSNs-mannose) in order to target breast tumors in vivo. Methods and Results: The structure of these nanoparticles is constituted of porphyrins J aggregates that allow two-photon spatiotemporal excitation of the nanoparticles. The therapeutic potential of such photoactivable nanoparticles was first studied in vitro, in human breast cancer cells in culture and then in vivo on zebrafish embryos bearing human tumors. These animal models were intravenously injected with 5 nL of a solution containing PORBSNs-mannose. An hour and half after the injection of photoactivable and targeted nanoparticles, the tumor areas were excited for few seconds with a two-photon beam induced focused laser. We observed strong tumor size decrease, with the involvement of apoptosis pathway activation.onclusion: We demonstrated the high targeting, imaging, and therapeutic potential of PORBSNs-mannose injected in the blood stream of zebrafish xenografted with human tumors.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1087107" status="OLD">
          <idno type="ISNI">0000000123688723</idno>
          <idno type="RNSR">200711918D</idno>
          <idno type="ROR">https://ror.org/028wq3277</idno>
          <orgName>Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier</orgName>
          <orgName type="acronym">ICGM</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Place Eugène Bataillon - Bâtiment 17 - CC1700- 34095 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.icgm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300370" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5253" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-24488" status="OLD">
          <idno type="RNSR">200711912X</idno>
          <idno type="ROR">https://ror.org/05d1e6v30</idno>
          <orgName>Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]</orgName>
          <orgName type="acronym">IBMM</orgName>
          <date type="start">2006-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Pharmacie - 15 Av. Charles Flahault - BP 14 491 - 34093 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibmm.univ-montp1.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300370" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5247" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-635" status="OLD">
          <idno type="IdRef">170479900</idno>
          <idno type="RNSR">199213330D</idno>
          <orgName>Laboratoire de Chimie des Substances Naturelles</orgName>
          <orgName type="acronym">LCSN</orgName>
          <date type="start">1992-01-01</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges Faculté des Sciences et Techniques 123, Avenue Albert Thomas 87060 LIMOGES Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr/lcsn</ref>
          </desc>
          <listRelation>
            <relation name="EA1069" active="#struct-5928" type="direct"/>
            <relation name="EA1069" active="#struct-302082" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-92874" status="VALID">
          <orgName>Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger]</orgName>
          <orgName type="acronym">USTHB</orgName>
          <desc>
            <address>
              <addrLine>BP 32 EL Alia 16111 Bab Ezzouar,  Alger</addrLine>
              <country key="DZ"/>
            </address>
            <ref type="url">http://www.usthb.dz/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1042414" status="OLD">
          <orgName>Optique et Matériaux</orgName>
          <orgName type="acronym">NEEL - OPTIMA</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Institut NEEL, 25 rue des Martyrs, BP 166,38042 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1042377" type="direct"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation name="UPR2940" active="#struct-441569" type="indirect"/>
            <relation active="#struct-445543" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300370" status="OLD">
          <idno type="ROR">https://ror.org/03sgyqj04</idno>
          <orgName>Ecole Nationale Supérieure de Chimie de Montpellier</orgName>
          <orgName type="acronym">ENSCM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>8 Rue de l'Ecole Normale 34296 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.enscm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-5928" status="VALID">
          <idno type="IdRef">026403315</idno>
          <idno type="ISNI">0000000121654861</idno>
          <idno type="ROR">https://ror.org/02cp04407</idno>
          <orgName>Université de Limoges</orgName>
          <orgName type="acronym">UNILIM</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302082" status="OLD">
          <idno type="IdRef">188832599</idno>
          <idno type="RNSR">201220465X</idno>
          <orgName>Génomique, Environnement, Immunité, Santé, Thérapeutique</orgName>
          <orgName type="acronym">GEIST FR CNRS 3503</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr/recherche/laboratoires/geist/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1042377" status="OLD">
          <idno type="IdRef">183998693</idno>
          <idno type="ISNI">0000 0004 0369 268X</idno>
          <idno type="RNSR">200717524X</idno>
          <idno type="ROR">https://ror.org/04dbzz632</idno>
          <orgName>Institut Néel</orgName>
          <orgName type="acronym">NEEL</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Institut NEEL, 25 rue des Martyrs, BP 166,38042 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.neel.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-89889" type="direct"/>
            <relation name="UPR2940" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>