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Article Dans Une Revue Nature Reviews Chemistry Année : 2019

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Résumé

Some Ru complexes have extremely promising anticancer or antibacterial properties, but the poor H2O solubility and/or low stability of many Ru complexes in aqueous solution under physiological conditions and/or metabolic or biodistribution profiles prevent their therapeutic use. To overcome these drawbacks, various strategies have been developed to improve the delivery of these compounds to their target tissues. The first strategy is based on physical encapsulation of Ru complexes in carriers, such as polymeric micelles, microparticles, nanoparticles and polymer–lipid hybrids, which enables the delivery and controlled release of the active Ru drug candidate. The second strategy involves covalent conjugation of the Ru complex to a polymer to give a prodrug that can be converted into the active drug at a more controllable rate. In this Review, we provide an overview of recent developments in polymer encapsulation of Ru complexes for biological and medicinal applications. We place particular emphasis on how polymer structure affects Ru delivery.
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Dates et versions

hal-02352951 , version 1 (07-11-2019)

Identifiants

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Elise Villemin, Yih Ching Ong, Christophe M Thomas, Gilles Gasser. Polymer encapsulation of ruthenium complexes for biological and medicinal applications. Nature Reviews Chemistry, 2019, 3 (4), pp.261-282. ⟨10.1038/s41570-019-0088-0⟩. ⟨hal-02352951⟩
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