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Journal Articles Cell Year : 2019

Cellular Senescence: Defining a Path Forward

1 NKUA - National and Kapodistrian University of Athens
2 University of Manchester [Manchester]
3 BRFAA - Biomedical Research Foundation of the Academy of Athens
4 CR-UK Beatson Institute - Institute of Cancer Sciences [Glasgow, UK]
5 Sanford Burnham Prebys Medical Discovery Institute
6 IOSI - Oncology Institute of Southern Switzerland
7 USI - Università della Svizzera italiana = University of Italian Switzerland
8 Unipd - Università degli Studi di Padova = University of Padua
9 VIMM - Veneto Institute of Molecular Medicine [Padova, Italy]
10 University of London [London]
11 Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis
12 Bart's and The London School of Medicine and Dentistry
13 QMUL - Queen Mary University of London
14 Buck Institute for Research on Aging
15 USC - Universidade de Santiago de Compostela [Spain]
16 CR CHUM - Centre de Recherche du Centre Hospitalier de l’Université de Montréal
17 UdeM - Université de Montréal
18 LMC - MRC London Institute of Medical Sciences
19 Imperial College London
20 RIMD - Research Institute for Microbial Diseases [Osaka, Japan]
21 Department of Molecular Cell Biology [Rehovot]
22 Robert and Arlene Kogod Center on Aging [Rochester, MN, USA]
23 VU - Vrije Universiteit Amsterdam [Amsterdam]
24 University of Melbourne
25 CAM - University of Cambridge [UK]
26 UMN - University of Minnesota [Twin Cities]
27 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
28 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
29 Kepler University Hospital
30 Brown University
31 Newcastle University [Newcastle]
32 UF - University of Florida [Gainesville]
33 IRB - Institute for Research in Biomedicine [Barcelona, Spain]
34 ICREA - Institució Catalana de Recerca i Estudis Avançats
35 University of Groningen [Groningen]
36 ERIBA - European Research Institute for the Biology of Ageing [Groningen]
Judith Campisi
John Sedivy
  • Function : Author


Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

Dates and versions

hal-02349008 , version 1 (05-11-2019)



Vassilis Gorgoulis, Peter Adams, Andrea Alimonti, Dorothy Bennett, Oliver Bischof, et al.. Cellular Senescence: Defining a Path Forward. Cell, 2019, 179 (4), pp.813-827. ⟨10.1016/j.cell.2019.10.005⟩. ⟨hal-02349008⟩


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