Article Dans Une Revue Nature Neuroscience Année : 2019

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

Résumé

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

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hal-02348080 , version 1 (12-11-2020)

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Kristina Valentinova, Anna Tchenio, Massimo Trusel, Joseph Clerke, Arnaud Lalive, et al.. Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability. Nature Neuroscience, 2019, 22 (7), pp.1053-1056. ⟨10.1038/s41593-019-0421-4⟩. ⟨hal-02348080⟩
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