Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein
Résumé
Background: The interaction of the peptide VGVAPG with the elastin binding protein is critically involved in aneurysm progression.
Results: A molecular model of this interaction is proposed and explored using a site-directed mutagenesis strategy.
Conclusion: Three residues, Leu-103, Arg-107, and Glu-137, of elastin binding protein are critical players in this interaction. Significance: Our data now allow the design of antagonists of VGVAPG.
Domaines
Biochimie, Biologie Moléculaire| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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