The development of brain magnetic resonance approaches in large animal models for preclinical research - Archive ouverte HAL
Article Dans Une Revue Animal Frontiers Année : 2019

The development of brain magnetic resonance approaches in large animal models for preclinical research

Résumé

Magnetic resonance imaging is a very powerful ap-proach to perform anatomical and functional imaging explorations. Large animal models are perfectly suited for MRI studies using clinical devices and these tools are cur-rently being developed and improved. Here we highlight an example of MRI to demonstrate the efficacy of gene therapy in sheep models of Batten disease, a pediatric neurodegenerative disease.
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hal-02347381 , version 1 (05-11-2019)

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Arsène Ella, David A Barrière, Hans Adriaensen, David Palmer, Tracy R Melzer, et al.. The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 2019, 9 (3), pp.44-51. ⟨10.1093/af/vfz024⟩. ⟨hal-02347381⟩
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