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Article Dans Une Revue eLife Année : 2018

Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

Résumé

Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response.
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Dates et versions

hal-02347047 , version 1 (05-11-2019)

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Wael Bazzi, Pierre Cattenoz, Claude Delaporte, Vasanthi Dasari, Rosy Sakr, et al.. Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila. eLife, 2018, 7, ⟨10.7554/eLife.34890⟩. ⟨hal-02347047⟩
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