Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments
Résumé
Graphical Abstract Highlights d A complex HER2 + breast cancer ecosystem is reconstituted and quantitatively described d The effects of the drug trastuzumab (Herceptin) are directly visualized ex vivo d Trastuzumab promotes long cancer-immune interactions and an ADCC immune response d Trastuzumab and CAFs have antagonist immunomodulation effects In Brief Inspired by the emerging technology of tumor-on-chip, Nguyen et al. reconstituted ex vivo a human tumor microenvironment (HER2 + breast cancer), characterized the ecosystem-level responses to the drug trastuzumab (Herceptin), and dissected the roles of stromal components (immune cells and fibroblasts), demonstrating the power of immunocompetent tumors-on-chip for preclinical drug studies.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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