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Article Dans Une Revue Organic Process Research and Development Année : 2014

A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores

F Giornal
  • Fonction : Auteur
G Landelle
  • Fonction : Auteur
N Lui
  • Fonction : Auteur
J Vors
  • Fonction : Auteur
S Pazenok
  • Fonction : Auteur

Résumé

The synthesis of 3,5-bis(fluoroalkyl)-pyrazoles as novel agrophores is described. Commercially available fluoroacetoacetates are treated with BF3-activated TFEDMA affording in a straightforward one-pot sequence pyrazole carboxylates in good yields and with excellent regioselectivity. The carboxylate intermediates have been converted into the corresponding pyrazolic acids and submitted to decarboxylation, affording valuable building blocks for the design of novel bioactive ingredients. The found process is suitable for scale up and preparation of compounds in kilogram quantity.

Domaines

Chimie organique
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Dates et versions

hal-02342504 , version 1 (31-10-2019)

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Citer

F Giornal, G Landelle, N Lui, J Vors, S Pazenok, et al.. A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores. Organic Process Research and Development, 2014, 18 (8), pp.1002-1009. ⟨10.1021/Op500102h⟩. ⟨hal-02342504⟩
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