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              <p>This paper addresses the problem of the integration of expert knowledge in a data mining process. We present the KTA ( integrating expert Knowledge in Transcriptome analysis) framework which allows the mining process to be driven by prior knowledge on the application domain. KTA is embedded in the MEDIANTE project for evaluating and using DNA microarrays, the CORESE semantic search engine and the ANNOT module which annotates scientific publications.</p>
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