This article presents a multimodal video corpus with the principal aim to model and predict the effects of aging in Mild Cognitive Impairment situation on pragmatic and communicative skills. We take as observable variables the verbal pragmatic markers and non-verbal pragmatic markers. This approach, at the interface of the psycholinguistics, cognitive sciences and rehabilitation medicine (speech-language pathology and therapy) is part of a longitudinal research process in an ecological situation (interviews conducted by close intimate of the elderly). In the first part of the article we present the linguistic, cognitive and social characteristics of aging in its continuum up to mild cognitive impairment and pathological disorders such as Alzheimer’s disease. In the second part, we develop a multimodal approach, in particular to inform and enrich speech and language therapy knowledge. Finally, we present our experimental design and preliminary results on two female participants over 75 years of age with mild cognitive impairment. Our general findings indicate that with aging, verbal pragmatic markers acquire an interactive function that allows people with Mild Cognitive Impairment to maintain intersubjective relationships with their interlocutor. In addition, at the non-verbal level, gestural manifestations are increasingly mobilized over time with a preference for non-verbal pragmatic markers with a referential function and an interactive function. One such non-verbal manifestation compensates for naming deficits, planning difficulties, discursive hitches; while another optimizes and maintains the interaction with the interlocutor. Clinicians have a duty to develop their professional practice through an evidence-based clinical approach whose main objective is to reconcile clinical practice with the best evidence from research (Dollaghan 2007). In the case of speech-language pathology, clinicians consider themselves very limited in this approach (Lof 2011; McCurtin 2011), especially for patients with Mild Cognitive Impairment (Mungas et al. 2010; Hopper 2013; Morello 2017) and more specifically when it comes to assessing or supporting language functions (Cummings 2014). The studies focusing on Mild Cognitive Impairment require longitudinal corpora i) to understand the naturally occurring evolutions in subjects, ii) the implication of the cognitive reserve in each individual, and iii) to take advantage of these parameters as evidence for research and earlier rehabilitation. We aim to show the benefits of linguistic and interactional scientific investigation methods through fragile aging, for health professionals and everyday caregivers.