NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles - Archive ouverte HAL
Article Dans Une Revue Journal of Materials Chemistry Année : 2011

NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

Xavier Le Guevel
Benjamin Hotzer
  • Fonction : Auteur
Gregor Jung
  • Fonction : Auteur

Résumé

In this paper we describe the synthesis and the optimisation of a new family of fluorescent core-shell nanoparticle using protein-stabilised gold nanoclusters. Fluorescent gold nanoclusters (<2 nm) entrapped in bovine serum albumin (BSA) protein were loaded in a 100 nm-silica nanoparticle with an optimal concentration of 3% (w/w). These nanoparticles kept the fluorescence properties of the metal clusters with a high Stokes shift and an emission in the near infrared region (l ¼ 670 nm). They were fully characterized and showed a high monodispersity and stability over more than 5 months. Steady-state fluorescence and lifetime measurements indicate the role of silica as a protective host to improve the photostability and the chemical stability of the fluorescent compound. This new label was taken up in tumor lung cells and tracked by a confocal microscope to show the great potential of this biolabel for sensing and imaging.
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Dates et versions

hal-02337861 , version 1 (29-10-2019)

Identifiants

  • HAL Id : hal-02337861 , version 1

Citer

Xavier Le Guevel, Benjamin Hotzer, Gregor Jung, Marc Schneider. NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles. Journal of Materials Chemistry, 2011. ⟨hal-02337861⟩
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