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Article Dans Une Revue Marine Pollution Bulletin Année : 2018

Whole genome sequences to assess the link between antibiotic and metal resistance in three coastal marine bacteria isolated from the mummichog gastrointestinal tract

Nicole A Lloyd
  • Fonction : Auteur
Tamar Barkay
  • Fonction : Auteur

Résumé

Antibiotic resistance is a global public health issue and metal exposure can co-select for antibiotic resistance. We examined genome sequences of three multi-drug and metal resistant bacteria: one Shewanella sp., and two Vibrio spp., isolated from the gut of the mummichog fish (Fundulus heteroclitus). Our primary goal was to understand the mechanisms of co-selection. Phenotypically, the strains showed elevated resistance to arsenate, mercury, and various types of β-lactams. The genomes contained genes of public health concern including one carbapenemase (bla OXA-48). Our analyses indicate that the co-selection phenotype is mediated by chromo-somal resistance genes and cross-resistance. No evidence of co-resistance was found; most resistance genes were chromosomally located. Moreover, the identification of many efflux pump gene homologs indicates that cross-resistance and/or co-regulation may further contribute to resistance. We suggest that the mummichog gut microbiota may be a source of clinically relevant antibiotic resistance genes.
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Dates et versions

hal-02335487 , version 1 (29-10-2019)

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Nicole A Lloyd, Sylvie Nazaret, Tamar Barkay. Whole genome sequences to assess the link between antibiotic and metal resistance in three coastal marine bacteria isolated from the mummichog gastrointestinal tract. Marine Pollution Bulletin, 2018, 135, pp.514-520. ⟨10.1016/j.marpolbul.2018.07.051⟩. ⟨hal-02335487⟩
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