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Proceedings/Recueil Des Communications Toxicon Année : 2018

A non-invasive method to appraise time-dependent effects of venom toxins on the mouse neuromuscular excitability in vivo

Résumé

The conventional methods, usually performed in vivo, provide limited information regarding sensory and neuromuscular excitability properties. In the present work, we review the new minimally invasive methods that have been improved to supplement the conventional electrophysiological methods. In particular, the automated sequence of multiple excitability tests developed by Professor Bostock (Qtrac©, Institute of Neurology, London, UK) to assess sensory and neuromuscular excitability in clinical neurophysiology, has been adapted to animal models in vivo, initially in rats and, more recently, in mice. This method is particularly appropriate for venom toxin injections and repeated recordings from the same animal cohort, making it a promising tool to appraise the progression of toxin effects, and that of an eventual given treatment, on the sensory and neuromuscular excitability of animal models in vivo. The in vivo efficiency in mice and long-term follow-up of the effects of sub-lethal doses of spider and conus venom toxins will be emphasised. It is indubitable that this method brings specific information regarding changes in ion transfer and membrane properties induced by a given venom toxin which, thereby, will help to a better characterization of toxin action on the sensory and neuromuscular excitability properties, in vivo.
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hal-02334359 , version 1 (15-02-2024)

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Tânia C. Gonçalves, Michel Partiseti, Denis Servent, Evelyne Benoit. A non-invasive method to appraise time-dependent effects of venom toxins on the mouse neuromuscular excitability in vivo. 23th Meeting on Toxinology « Toxins: Immunity, Inflammation and Pain » organized by the French Society of Toxinology (SFET), Toxicon, 149, pp.104, 2018, ⟨10.1016/j.toxicon.2018.02.030⟩. ⟨hal-02334359⟩
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