We demonstrate the successful electrodeposition of Cu nanodendrite foams onto a series of lithographically formed gold band electrodes at negative overpotentials (-5V and-6V) in an acidic environment. The nanodendrite foams were deposited onto two different integrated microelectrode arrays fabricated using standard lithographic techniques. Each electrode consisted of 17 gold band electrodes deposited onto a silicon wafer substrate, labelled BA5 (with a width of 5 µm and a length of 250 µm) and BA10 (with a width of 10 µm and a length of 500 µm). Prior to Cu deposition the gold electrodes were characterized by scanning electron microscopy (SEM) in order to evaluate the morphology of each design and by cyclic voltammetry (CV) in order to investigate their diffusion profiles. After Cu deposition the resulting 3D foam structures were studied using SEM, XPS and EDX. The Cu foam/Au microelectrodes were then used for the electrocatalytic detection of glucose via oxidation at a potential of +0.45 V vs. Ag/AgCl in an alkaline medium. It was found that both types of electrode arrays used showed excellent analytical performance in terms of sensitivity, reproducibility and stability in comparison with the best performances reported in the literature. In particular, the BA5-CuFoam electrode exhibited an outstanding sensitivity of 10,630 µA mM-1 cm-2 towards glucose with a wide linear range up to 22.55 mM. The performance of this new type of electrochemical sensor is attributed to a combination of the use of the very high surface area Cu nanodendrite foam and the enhanced radial distribution profile associated with the use of the smaller band microfabricated electrodes. Additionally, both biosensors also showed a strong resistance to the poisoning effects of chlorine ions and excellent stability over a period of three months.