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Article Dans Une Revue Nature Methods Année : 2014

3D genome reconstruction from chromosomal contacts

Reconstructing 3D genomes from chromosomal contact maps

Résumé

A computational challenge raised by chromosome conformation capture (3C) experiments is to reconstruct spatial distances and three-dimensional genome structures from observed contacts between genomic loci. We propose a two-step algorithm, ShRec3D, and assess its accuracy using both in silico data and human genome-wide 3C (Hi-C) data. This algorithm avoids convergence issues, accommodates sparse and noisy contact maps, and is orders of magnitude faster than existing methods.
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Dates et versions

hal-02324120 , version 1 (23-10-2019)

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Annick Lesne, Julien Riposo, Paul Roger, Axel Cournac, Julien Mozziconacci. 3D genome reconstruction from chromosomal contacts. Nature Methods, 2014, 11, pp.1141-1143. ⟨10.1038/NMETH.3104⟩. ⟨hal-02324120⟩
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