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            <title xml:lang="en">The untold stories of the speech gene, the FOXP2 cancer gene.</title>
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            <idno type="stamp" n="U968" corresp="INSERM">Institut de la vision</idno>
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                <title xml:lang="en">The untold stories of the speech gene, the FOXP2 cancer gene.</title>
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              <p>FOXP2 encodes a transcription factor involved in speech and language acquisition.Growing evidence now suggests that dysregulated FOXP2 activity may also beinstrumental in human oncogenesis, along the lines of other cardinaldevelopmental transcription factors such as DLX5 and DLX6 [1-4]. Several FOXPfamilymembers are directly involved during cancer initiation, maintenance andprogression in the adult [5-8]. This may comprise either a pro-oncogenic activityor a deficient tumor-suppressor role, depending upon cell types and associatedsignaling pathways. While FOXP2 is expressed in numerous cell types, itsexpression has been found to be down-regulated in breast cancer [9],hepatocellular carcinoma [8] and gastric cancer biopsies [10]. Conversely,overexpressed FOXP2 has been reported in multiple myelomas, MGUS (MonoclonalGammopathy of Undetermined Significance), several subtypes of lymphomas [5,11],as well as in neuroblastomas [12] and ERG fusion-negative prostate cancers [13]. According to functional evidences reported in breast cancer [9] and survey ofrecent transcriptomic and proteomic analyses of different tumor biopsies, wepostulate that FOXP2 dysregulation may play a main role throughout cancerinitiation and progression. In some cancer conditions, FOXP2 levels are nowconsidered as a critical diagnostic marker of neoplastic cells, and in manysituations, they even bear strong prognostic value [5]. Whether FOXP2 may furtherbecome a therapeutic target is an actively explored lead. Knowledge reviewed heremay help improve our understanding of FOXP2 roles during oncogenesis and provide cues for diagnostic, prognostic and therapeutic analyses.</p>
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