Cathepsin-Sensitive Nanoscale Drug Delivery Systems for Cancer Therapy and other Diseases - Archive ouverte HAL
Article Dans Une Revue Advanced Drug Delivery Reviews Année : 2019

Cathepsin-Sensitive Nanoscale Drug Delivery Systems for Cancer Therapy and other Diseases

Résumé

Cathepsins are an important category of enzymes that have attracted great attention for the delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug delivery systems. These proteases can be utilized for instance through actuation of polymer-drug conjugates (e.g., triggering the drug release) to bypass limitations of many drug candidates. A substantial amount of work has been witnessed in the design and the evaluation of Cathepsin-sensitive drug delivery systems, especially based on the tetra-peptide sequence (Gly-Phe-Leu-Gly, GFLG) which has been extensively used as a spacer that can be cleaved in the presence of Cathepsin B. This Review Article will give an in-depth overview of the design and the biological evaluation of Cathepsin-sensitive drug delivery systems and their application in different pathologies including cancer before discussing Cathepsin B-cleavable prodrugs under clinical trials.

Domaines

Pharmacologie
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Dates et versions

hal-02323749 , version 1 (21-10-2019)

Identifiants

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Divya Dheer, Julien Nicolas, Ravi Shankar. Cathepsin-Sensitive Nanoscale Drug Delivery Systems for Cancer Therapy and other Diseases. Advanced Drug Delivery Reviews, 2019, 151-152, pp.130-151. ⟨10.1016/j.addr.2019.01.010⟩. ⟨hal-02323749⟩
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