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            <title xml:lang="en">SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae</title>
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                <forename type="first">Anita</forename>
                <surname>Minnen</surname>
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                <forename type="first">Laetitia</forename>
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            <funder>L.A. was supported by a postdoctoral fellowship from the European Molecular Biology Organization (EMBO ALTF 611-2009).</funder>
            <funder>Work in the lab of J.W.V. is supported by an EU Marie-Curie Reintegration Fellowship, a Sysmo2 Grant (NWO-ALW/ERASysBio), a Horizon grant (ZonMW) and by a VENI fellowship (NWO-ALW).</funder>
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                <title xml:lang="en">SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae</title>
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                    <forename type="first">Laetitia</forename>
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                    <forename type="first">Jan-Willem</forename>
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                <title level="j">Molecular Microbiology</title>
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              <p>Segregation of replicated chromosomes is an essential process in all organisms. How bacteria, such as the oval-shaped human pathogen Streptococcus pneumoniae, efficiently segregate their chromosomes is poorly understood. Here we show that the pneumococcal homologue of the DNA-binding protein ParB recruits S. pneumoniae condensin (SMC) to centromere-like DNA sequences (parS) that are located near the origin of replication, in a similar fashion as was shown for the rod-shaped model bacterium Bacillus subtilis. In contrast to B. subtilis, smc is not essential in S. pneumoniae, and delta-smc cells do not show an increased sensitivity to gyrase inhibitors or high temperatures. However, deletion of smc and/or parB results in a mild chromosome segregation defect. Our results show that S. pneumoniae contains a functional chromosome segregation machine that promotes efficient chromosome segregation by recruitment of SMC via ParB. Intriguingly, the data indicate that other, as of yet unknown mechanisms, are at play to ensure proper chromosome segregation in this organism.</p>
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