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Article Dans Une Revue Behavioural Brain Research Année : 1998

Timed active avoidance learning in lurcher mutant mice

Résumé

Lurcher mutant mice (+/Lc) which exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nuclei were subjected to an active avoidance learning task; the animals' avoidance response must occur within a small time window after a short or a long delay. The control mice needed a mean of 8.3 sessions of 10 trials (short delay group) and of 11.8 sessions (long delay group) and showed good retention after a 24 h interval. When subjected to the same number of sessions, the +/Lc mice were unable to learn the timing task. However, a subgroup of lurcher mutants was able to learn after a high number of sessions (25.4 sessions as a mean). There was no intergroup difference in the standard version of one-way active avoidance. These results indicate that the cerebellar cortex is involved in time processing during active avoidance. The cerebellum may be part of a loop including the cerebral cortex known to be involved in time perception. An alternative explanation is that the cerebellar mutant animals had persevering tendencies acquired during performance of the one-way avoidance task.

Dates et versions

hal-02314095 , version 1 (11-10-2019)

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Citer

Vincent Monfort, P. Chapillon, D. Mellier, R. Lalonde, J. Caston. Timed active avoidance learning in lurcher mutant mice. Behavioural Brain Research, 1998, 91 (1-2), pp.165-172. ⟨10.1016/s0166-4328(97)00113-7⟩. ⟨hal-02314095⟩
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