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Article Dans Une Revue Journal of Pharmacokinetics and Pharmacodynamics Année : 2014

Population pharmacokinetic analysis of fexofenadine in Japanese pediatric patients

Sonia Khier
David Fabre
  • Fonction : Auteur

Résumé

A population pharmacokinetic analysis was conducted to characterize the pharmacokinetics of fexo-fenadine in Japanese pediatric patients (6 months through 16 years) with perennial allergic rhinitis or atopic derma-titis. The dataset was composed of 515 patients (including 109 adults), for a total of 1,080 concentration-time points. The analysis was performed with NONMEM using the SAEM method. Several structural models and residual error models were evaluated. The relationship between the individual estimates and the potential covariates was then investigated: demographic and pathophysiologic characteristics were tested as potential model covariates (forward selection method). The qualification of the model was performed using visual predictive check and bootstrap. A two-compartment disposition model with first-order absorption best fitted the data. The inter-individual variability was modeled through an exponential error model for all parameters (except for ka for which no inter-individual term could be estimated), while a proportional error model was used to model the residual variability. The final model included two covariates on elimination clearance and one on the intercompartmental clearance. CL/F was related to BSA and patient's age (expressed in months) Q/F was also related to BSA. Once the model was correctly qualified, exposure parameters such as C max and AUC s were computed and compared between each age subgroup and between Japanese and Caucasians patients. These comparisons did not reveal any major difference (less than 50 %) between subgroups.
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Dates et versions

hal-02309713 , version 1 (09-10-2019)

Identifiants

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Jean-Marie Martinez, Sonia Khier, Shigemichi Morita, Clémence Rauch, David Fabre. Population pharmacokinetic analysis of fexofenadine in Japanese pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics, 2014, 41 (2), pp.187-195. ⟨10.1007/s10928-014-9356-2⟩. ⟨hal-02309713⟩

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