Enantiomeric visualization using proton-decoupled natural abundance deuterium NMR in poly(γ-benzyl-l-glutamate) liquid crystalline solutions
Résumé
We report the first visualization of chiral molecules oriented in a polypeptide liquid crystalline system (PBLG)
using proton-decoupled natural abundance deuterium NMR. The chiral discrimination is observed through measurements
of the quadrupolar splitting differences and we demonstrate that the sensitivity of natural abundance
deuterium NMR is sufficient to measure the differentiai ordering effects (DOEs) without the need for isotopie
enrichment. The feasibility and the potential of this novel method were investigated using a 5.87 T spectrometer
(proton frequency 250 MHz). Severa! examples of chiral discrimination are presented and particular emphasis is
given to demonstrate the potential of this approach.