<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02282339</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T05:34:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Assessment of individual and mixed toxicity of bromoform, tribromoacetic-acid and 2,4,6 tribromophenol, on the embryo-larval development of Paracentrotus lividus sea urchin</title>
            <author role="aut">
              <persName>
                <forename type="first">Karine</forename>
                <surname>Lebaron</surname>
              </persName>
              <email type="md5">c97f87fa132d6034b6c2d440f3ca0b24</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="numeric">1034861</idno>
              <idno type="halauthorid" notation="string">1402022-1034861</idno>
              <affiliation ref="#struct-220811"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lilia</forename>
                <surname>Mechiri</surname>
              </persName>
              <idno type="halauthorid">1648397-0</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Simone</forename>
                <surname>Richard</surname>
              </persName>
              <email type="md5">508d93c0aa02d122786513891df7c1db</email>
              <email type="domain">univ-tln.fr</email>
              <idno type="idhal" notation="string">simone-richard</idno>
              <idno type="idhal" notation="numeric">21483</idno>
              <idno type="halauthorid" notation="string">41609-21483</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0450-9256</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Annabelle</forename>
                <surname>Austruy</surname>
              </persName>
              <email type="md5">42b828eb2dada63400a721f522815c3d</email>
              <email type="domain">institut-ecocitoyen.fr</email>
              <idno type="idhal" notation="numeric">767132</idno>
              <idno type="halauthorid" notation="string">668252-767132</idno>
              <idno type="IDREF">https://www.idref.fr/164510001</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7939-8036</idno>
              <affiliation ref="#struct-577275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Luc</forename>
                <surname>Boudenne</surname>
              </persName>
              <email type="md5">c3f24f16bc7e79e556d8f2b70e663811</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">jean-luc-boudenne</idno>
              <idno type="idhal" notation="numeric">10885</idno>
              <idno type="halauthorid" notation="string">527542-10885</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6150-4171</idno>
              <idno type="IDREF">https://www.idref.fr/145020215</idno>
              <affiliation ref="#struct-220811"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphane</forename>
                <surname>Coupé</surname>
              </persName>
              <email type="md5">1f4e9755843654af791d33812f344770</email>
              <email type="domain">univ-tln.fr</email>
              <idno type="idhal" notation="string">stephane-coupe</idno>
              <idno type="idhal" notation="numeric">19952</idno>
              <idno type="halauthorid" notation="string">31150-19952</idno>
              <idno type="IDREF">https://www.idref.fr/102195749</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7774-5698</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean-Luc</forename>
                <surname>Boudenne</surname>
              </persName>
              <email type="md5">c3f24f16bc7e79e556d8f2b70e663811</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
            <funder ref="#projanr-42627"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-09-09 20:55:40</date>
              <date type="whenModified">2026-03-30 11:42:53</date>
              <date type="whenReleased">2019-09-10 10:00:18</date>
              <date type="whenProduced">2019</date>
              <date type="whenEndEmbargoed">2019-09-09</date>
              <ref type="file" target="https://hal.science/hal-02282339v1/document">
                <date notBefore="2019-09-09"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02282339v1/file/ESPR_Lebaron%20et%20al_2019_HAL.pdf" id="file-2282339-2203420">
                <date notBefore="2019-09-09"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-02282339/file/ESPR_Lebaron%20et%20al_2019_HAL.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="464298">
                <persName>
                  <forename>Jean-Luc</forename>
                  <surname>Boudenne</surname>
                </persName>
                <email type="md5">c3f24f16bc7e79e556d8f2b70e663811</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02282339</idno>
            <idno type="halUri">https://hal.science/hal-02282339</idno>
            <idno type="halBibtex">lebaron:hal-02282339</idno>
            <idno type="halRefHtml">&lt;i&gt;Environmental Science and Pollution Research&lt;/i&gt;, 2019, 26 (20), pp.20573-20580. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s11356-019-05279-8"&gt;&amp;#x27E8;10.1007/s11356-019-05279-8&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Environmental Science and Pollution Research, 2019, 26 (20), pp.20573-20580. &amp;#x27E8;10.1007/s11356-019-05279-8&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2282339-2203420"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno>
            <idno type="stamp" n="SDE">Sciences De l'Environnement</idno>
            <idno type="stamp" n="INSU">INSU - Institut National des Sciences de l'Univers</idno>
            <idno type="stamp" n="UNIV-TLN">Université de Toulon</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="MIO" corresp="OSU-INSTITUT-PYTHEAS">Institut Méditerranéen d'Oceanologie - Mediterranean Institute of Oceanography (MIO)</idno>
            <idno type="stamp" n="OSU-INSTITUT-PYTHEAS">OSU INSTITUT PYTHEAS</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="LCE">Laboratoire de Chimie de l'Environnement</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="MIO-EMBIO" corresp="MIO">Ecologie Marine et BIOdiversité (EMBIO)</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="ANR-OCEANS-15TO18" corresp="ANR-OCEANS">ANR-OCEANS-15TO18</idno>
            <idno type="stamp" n="ANR-OCEANS">ANR-OCEANS</idno>
            <idno type="stamp" n="ANR-ONE-HEALTH">ANR-ONE-HEALTH</idno>
            <idno type="stamp" n="ANR-ONE-HEALTH-REF-ANR" corresp="ANR-ONE-HEALTH">ANR-ONE-HEALTH-REF-ANR</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Assessment of individual and mixed toxicity of bromoform, tribromoacetic-acid and 2,4,6 tribromophenol, on the embryo-larval development of Paracentrotus lividus sea urchin</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Karine</forename>
                    <surname>Lebaron</surname>
                  </persName>
                  <email type="md5">c97f87fa132d6034b6c2d440f3ca0b24</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="numeric">1034861</idno>
                  <idno type="halauthorid" notation="string">1402022-1034861</idno>
                  <affiliation ref="#struct-220811"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lilia</forename>
                    <surname>Mechiri</surname>
                  </persName>
                  <idno type="halauthorid">1648397-0</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Simone</forename>
                    <surname>Richard</surname>
                  </persName>
                  <email type="md5">508d93c0aa02d122786513891df7c1db</email>
                  <email type="domain">univ-tln.fr</email>
                  <idno type="idhal" notation="string">simone-richard</idno>
                  <idno type="idhal" notation="numeric">21483</idno>
                  <idno type="halauthorid" notation="string">41609-21483</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0450-9256</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Annabelle</forename>
                    <surname>Austruy</surname>
                  </persName>
                  <email type="md5">42b828eb2dada63400a721f522815c3d</email>
                  <email type="domain">institut-ecocitoyen.fr</email>
                  <idno type="idhal" notation="numeric">767132</idno>
                  <idno type="halauthorid" notation="string">668252-767132</idno>
                  <idno type="IDREF">https://www.idref.fr/164510001</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7939-8036</idno>
                  <affiliation ref="#struct-577275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Luc</forename>
                    <surname>Boudenne</surname>
                  </persName>
                  <email type="md5">c3f24f16bc7e79e556d8f2b70e663811</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">jean-luc-boudenne</idno>
                  <idno type="idhal" notation="numeric">10885</idno>
                  <idno type="halauthorid" notation="string">527542-10885</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6150-4171</idno>
                  <idno type="IDREF">https://www.idref.fr/145020215</idno>
                  <affiliation ref="#struct-220811"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphane</forename>
                    <surname>Coupé</surname>
                  </persName>
                  <email type="md5">1f4e9755843654af791d33812f344770</email>
                  <email type="domain">univ-tln.fr</email>
                  <idno type="idhal" notation="string">stephane-coupe</idno>
                  <idno type="idhal" notation="numeric">19952</idno>
                  <idno type="halauthorid" notation="string">31150-19952</idno>
                  <idno type="IDREF">https://www.idref.fr/102195749</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7774-5698</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12952</idno>
                <idno type="issn">0944-1344</idno>
                <idno type="eissn">1614-7499</idno>
                <title level="j">Environmental Science and Pollution Research</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">26</biblScope>
                  <biblScope unit="issue">20</biblScope>
                  <biblScope unit="pp">20573-20580</biblScope>
                  <date type="datePub">2019</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s11356-019-05279-8</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Disinfection by-products</term>
                <term xml:lang="en">Seawater</term>
                <term xml:lang="en">Tribromophenol</term>
                <term xml:lang="en">Bromoform</term>
                <term xml:lang="en">Tribromoacetic acid</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.tox.eco">Life Sciences [q-bio]/Toxicology/Ecotoxicology</classCode>
              <classCode scheme="halDomain" n="sde.be">Environmental Sciences/Biodiversity and Ecology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Water chlorination is the most widely used technique to avoid microbial contamination and biofouling. Adding chlorine in bromide-rich waters leads to the rapid oxidation of bromide ions and leads to the formation of brominated disinfection by products (bromo-DBPs) that exert adverse effects on various biological models. Bromo-DBPs are regularly encountered within industrialized embayments, potentially impacting marine organisms. Of these, bromoform, tribromoacetic acid and tribromophenol are among the most prevalent. In the present study, we tested the potential toxicity and genotoxicity of these disinfection by-products, using sea urchin, Paracentrotus lividus, embryos. We highlighted that tribromophenol showed higher toxicity compared to bromoform and tribromoacetic acid. Furthermore, a synergistic effect was detected when tested in combination. Pluteus cells exposed for 1h to mixtures of DPBs at several concentrations demonstrated significant DNA damage. Finally, when compared to a non-exposed population, sea urchins living in a bromo-DPB-polluted area produced more resistant progenies, as if they were locally adapted. This hypothesis remains to be tested in order to better understand the obvious impact of bromo-DBPs environments on marine wildlife.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-220811" status="VALID">
          <idno type="ISNI">000000040385962X</idno>
          <idno type="RNSR">201220353A</idno>
          <idno type="ROR">https://ror.org/02pr0xw82</idno>
          <orgName>Laboratoire Chimie de l'environnement</orgName>
          <orgName type="acronym">LCE</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Case 293 place Victor Hugo 13331 Marseille Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lce.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR7376 / FRE3416" active="#struct-198056" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR7376 / FRE3416" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-191652" status="VALID">
          <idno type="IdRef">167663925</idno>
          <idno type="ISNI">0000000417586271</idno>
          <idno type="RNSR">201220349W</idno>
          <idno type="ROR">https://ror.org/05258q350</idno>
          <idno type="Wikidata">Q3152368</idno>
          <orgName>Institut méditerranéen d'océanologie</orgName>
          <orgName type="acronym">MIO</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>M.I.O. Institut Méditerranéen d'Océanologie Bâtiment Méditerranée163 Avenue de Luminy13288 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.mio.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_D235" active="#struct-67872" type="direct"/>
            <relation name="UM110" active="#struct-198056" type="direct"/>
            <relation name="UMR7294" active="#struct-300045" type="direct"/>
            <relation name="UMR7294" active="#struct-303091" type="direct"/>
            <relation name="UMR7294" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-577275" status="VALID">
          <orgName>Institut Ecocitoyen pour la Connaissance des Pollutions [Fos-sur-Mer]</orgName>
          <desc>
            <address>
              <addrLine>Centre de vie la Fossette RD 268, 13270 Fos-sur-Mer</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-ecocitoyen.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300045" status="VALID">
          <idno type="IdRef">029349265</idno>
          <idno type="ISNI">0000 0001 2154 1736</idno>
          <idno type="ROR">https://ror.org/04kdfz702</idno>
          <idno type="Wikidata">Q3152437</idno>
          <orgName>Institut national des sciences de l'Univers</orgName>
          <orgName type="acronym">INSU - CNRS</orgName>
          <date type="start">2007-04-19</date>
          <desc>
            <address>
              <addrLine>INSU-CNRS3 rue Michel-Ange, 75794 Paris Cedex 16</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.insu.cnrs.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303091" status="VALID">
          <idno type="IdRef">031122337</idno>
          <idno type="ROR">https://ror.org/02m9kbe37</idno>
          <orgName>Université de Toulon</orgName>
          <orgName type="acronym">UTLN</orgName>
          <desc>
            <address>
              <addrLine>Avenue de l'Université - BP 20132 - 83957 La Garde Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tln.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-42627" status="VALID">
          <idno type="anr">ANR-16-CE34-0009</idno>
          <orgName>FOS-SEA</orgName>
          <desc>Evalution du risque environnemental lié à la maîtrise du biofouling en zone littorale méditerranéenne</desc>
          <date type="start">2016</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>