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Article Dans Une Revue Cancer Epidemiology, Biomarkers and Prevention Année : 2019

Plasma metabolomic signatures associated with long-term breast cancer risk in the SU.VI.MAX prospective cohort

Aïcha Demidem
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Adrien Rossary
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Marie-Paule Vasson
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Résumé

BACKGROUND: Breast cancer is a major cause of death in occidental women. The role of metabolism in breast cancer etiology remains unclear. Metabolomics may help to elucidate novel biological pathways and identify new biomarkers in order to predict breast cancer long before symptoms appear. The aim of this study was to investigate whether untargeted metabolomic signatures from blood draws of healthy women could contribute to better understand and predict the long-term risk of developing breast cancer. METHODS: A nested case-control study was conducted within the SU.VI.MAX prospective cohort (13 years of follow-up) to analyze baseline plasma samples of 211 incident breast cancer cases and 211 matched controls by LC-MS mass spectrometry. Multivariable conditional logistic regression models were computed. RESULTS: 3565 ions were detected and 1221 were retained for statistical analysis. 73 ions were associated with breast cancer risk (p<0.01, FDR

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Cancer
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Dates et versions

hal-02282293 , version 1 (09-09-2019)

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Citer

Lucie Lécuyer, Céline Dalle, Bernard Lyan, Aïcha Demidem, Adrien Rossary, et al.. Plasma metabolomic signatures associated with long-term breast cancer risk in the SU.VI.MAX prospective cohort. Cancer Epidemiology, Biomarkers and Prevention, 2019, 28 (8), pp.1300-1307. ⟨10.1158/1055-9965.epi-19-0154⟩. ⟨hal-02282293⟩
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