In the last decades, a growing attention was paid towards the exploitation of other lithic raw materials than flint. In this context, the lithic assemblage of Payre level D, dated to the end of the MIS 6, offers the opportunity to make some considerations about the modalities of a discoid technology on various lithic raw materials. Payre is a very well-known Middle Palaeolithic site located on the right edge of the Middle Rhône valley. Three main archaeological levels attest an intense human frequentation of the site between the end of MIS 8 and the beginning of MIS 5. The rich faunal and lithic assemblages, recovered during systematic excavations from 1990 to 2002, have been deeply analysed for a precise understanding of the site formation processes and the modalities of the human occupation of the area. The exploitation of different local and semi-local raw materials made Payre an interesting case to observe how lithic resources with different petrographic characteristics were exploited by the Neanderthal groups. The present work aims to observe how the lithic raw materials have affected the discoid reduction sequences. This knapping method is widely attested in archaeological level D, the last large phase of human occupation at Payre. Among the different raw materials exploited (flint, vein quartz, quartzite, basalt and limestone), the discoid method is just applied on flint and vein quartz. The new technological analysis carried out focuses for the first time on the characteristics of the discoid technology present in level D and on the differences in discoid reduction sequences depending on the raw materials. The results indicate some expedients used to apply discoid reduction strategies on vein quartz and adapt this technology to the features of a coarse-grained stone. The use of such expedients testifies a large capability to manage the raw materials but also of the discoid method itself. Results allow to make considerations on some of the criteria proper to the technological definition of the method.