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Article Dans Une Revue AJP - Gastrointestinal and Liver Physiology Année : 2000

The endothelin system in normal human colon

Résumé

Endothelin (ET)-1 is a potent vasoconstrictor and mitogenic peptide that has a variety of biological effects in noncardiovascular tissues. The precise cellular distribution of the ET-1 system in the wall of the normal human colon was studied to identify the physiological role of ET in the gut. In situ hybridization revealed ET-converting enzyme-1 (ECE-1) mRNA in all vessels, the colon epithelium, and macrophages. Prepro-ET-1 (PPET-1) mRNA had a similar distribution except for a scattered signal in mucosal microvessels. ET(A) and ET(B) receptor mRNAs were mainly in the lamina propria, pericryptal myofibroblasts, microvessels, and mononuclear cells, with ET(A) mRNA more abundant than ET(B) mRNA. (125)I-ET-1 binding showed ET(B) along the crypts and in nerve fibers descending from the ganglionic plexus that contained PPET-1, ECE-1, and ET(B) transcripts, whereas glia contained ET(A) receptors. The finding of the entire ET system in the normal mucosa suggests its implication in some characteristic functions of the colon and its secretion as both a neuroactive and a vasoactive peptide.
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Dates et versions

hal-02279019 , version 1 (04-09-2019)

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Giorgia Egidy, Lucienne Juillerat-Jeanneret, Petra Korth, Fred T. Bosman, Florence Pinet. The endothelin system in normal human colon. AJP - Gastrointestinal and Liver Physiology, 2000, 279 (1), pp.G211-G222. ⟨10.1152/ajpgi.2000.279.1.G211⟩. ⟨hal-02279019⟩

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