Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.
Résumé
We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
Mots clés
Aspergillus fumigatus
CT
fungi
galactomannan antigen
graft-versus-host disease
hematopoietic stem-cell transplantation
immunocompromised patients
invasive fungal disease
isavuconazole
mucormycosis
qPCR
quantitative PCR
France
treatment failure
Rhizomucor
acute myeloid leukemia
antimicrobial resistance
aspergillosis
computed tomography
death
fungal co-infection
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