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                <term xml:lang="en">Alcohol use disorder</term>
                <term xml:lang="en">Cerebellum</term>
                <term xml:lang="en">Fronto-cerebellar circuit</term>
                <term xml:lang="en">Hypermetabolism</term>
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              <p>&lt;b&gt;BACKGROUND: &lt;/b&gt;&lt;br /&gt;Despite severe structural brain abnormalities within the fronto-cerebellar circuit (FCC), cerebellar metabolism studied with FDG-PET is relatively preserved in patients with alcohol use disorder (AUD). The compensatory role of the cerebellum has been explored mainly through fMRIexamination of AUD patients with preserved level of performance. The present study aims at examining cerebellar metabolism and its relationship with regional brain metabolism and neuropsychological functioning in AUD patients.&lt;br /&gt;&lt;br /&gt;&lt;b&gt;METHODS: &lt;/b&gt;&lt;br /&gt;Thirty-two recently detoxified AUD patients and 23 controls underwent an FDG-PET examination at rest. Participants also performed a neuropsychological battery assessing executive functions, verbal memory and ataxia.&lt;br /&gt;&lt;br /&gt;&lt;b&gt;RESULTS: &lt;/b&gt;&lt;br /&gt;Compared to controls, AUD patients had higher glucose-uptake in the cerebellar lobules VIII, in association with hypometabolism notably in several nodes of the FCC. Cerebellar hypermetabolism correlated negatively with regional hypometabolism in the premotor and frontal cortices. This pattern of regional hypermetabolism and hypometabolism related to ataxia and working memory deficits.&lt;br /&gt;&lt;br /&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;&lt;br /&gt;These specific brain-behaviour relationships do not fulfil the criteria for brain compensatory processes. Cerebellar hypermetabolism may rather reflect the involvement of different pathological mechanisms, leading to a maladaptive plasticity phenomenon within the FCC in AUD patients who are early in abstinence. Further studies are required to examine the contributions of structural and functional connectivity alterations in the cerebellar hypermetabolism and the changes of these pathological mechanisms with abstinence or relapse.</p>
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