<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02269754</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T01:27:58+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">High inhaled oxygen concentration quadruples exhaled CO in healthy volunteers monitored by a highly sensitive laser spectrometer</title>
            <author role="aut">
              <persName>
                <forename type="first">Vivien</forename>
                <surname>Brenckmann</surname>
              </persName>
              <email type="md5">1ae09e540a002eef5259270238160946</email>
              <email type="domain">hotmail.fr</email>
              <idno type="idhal" notation="numeric">986756</idno>
              <idno type="halauthorid" notation="string">1048461-986756</idno>
              <affiliation ref="#struct-97332"/>
              <affiliation ref="#struct-388395"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Irène</forename>
                <surname>Ventrillard</surname>
              </persName>
              <email type="md5">9ed1f21cecfffad787a3c196defb13f9</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">771600</idno>
              <idno type="halauthorid" notation="string">829732-771600</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2114-9563</idno>
              <affiliation ref="#struct-144285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniele</forename>
                <surname>Romanini</surname>
              </persName>
              <email type="md5">364018c9caabfc158310c107a5c669fb</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="string">danielromanini</idno>
              <idno type="idhal" notation="numeric">844153</idno>
              <idno type="halauthorid" notation="string">239900-844153</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6874-8304</idno>
              <idno type="IDREF">https://www.idref.fr/083260471</idno>
              <idno type="VIAF">https://viaf.org/viaf/201016012</idno>
              <affiliation ref="#struct-144285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kévin</forename>
                <surname>Jaulin</surname>
              </persName>
              <idno type="halauthorid">1638862-0</idno>
              <affiliation ref="#struct-569339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascale</forename>
                <surname>Calabrese</surname>
              </persName>
              <idno type="halauthorid">727746-0</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Briot</surname>
              </persName>
              <email type="md5">9685ff6c859a05eab240011e2e4426e7</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">808688</idno>
              <idno type="halauthorid" notation="string">238960-808688</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5579-7665</idno>
              <idno type="IDREF">https://www.idref.fr/091482127</idno>
              <affiliation ref="#struct-388395"/>
              <affiliation ref="#struct-257328"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Raphael</forename>
                <surname>Briot</surname>
              </persName>
              <email type="md5">9685ff6c859a05eab240011e2e4426e7</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-08-23 11:24:08</date>
              <date type="whenModified">2026-03-26 16:30:05</date>
              <date type="whenReleased">2019-08-23 13:42:24</date>
              <date type="whenProduced">2019-08-22</date>
              <date type="whenEndEmbargoed">2019-08-23</date>
              <ref type="file" target="https://hal.science/hal-02269754v1/document">
                <date notBefore="2019-08-23"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-02269754v1/file/Brenckmann_et_al-2019-Scientific_Reports.pdf" id="file-2269754-2192947">
                <date notBefore="2019-08-23"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.1038/s41598-019-48789-8"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="118232">
                <persName>
                  <forename>Raphael</forename>
                  <surname>Briot</surname>
                </persName>
                <email type="md5">9685ff6c859a05eab240011e2e4426e7</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02269754</idno>
            <idno type="halUri">https://hal.science/hal-02269754</idno>
            <idno type="halBibtex">brenckmann:hal-02269754</idno>
            <idno type="halRefHtml">&lt;i&gt;Scientific Reports&lt;/i&gt;, 2019, 9 (1), &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41598-019-48789-8"&gt;&amp;#x27E8;10.1038/s41598-019-48789-8&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Scientific Reports, 2019, 9 (1), &amp;#x27E8;10.1038/s41598-019-48789-8&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2269754-2192947"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="LIPHY" corresp="CNRS">Laboratoire interdisciplinaire de Physique</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">High inhaled oxygen concentration quadruples exhaled CO in healthy volunteers monitored by a highly sensitive laser spectrometer</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Vivien</forename>
                    <surname>Brenckmann</surname>
                  </persName>
                  <email type="md5">1ae09e540a002eef5259270238160946</email>
                  <email type="domain">hotmail.fr</email>
                  <idno type="idhal" notation="numeric">986756</idno>
                  <idno type="halauthorid" notation="string">1048461-986756</idno>
                  <affiliation ref="#struct-97332"/>
                  <affiliation ref="#struct-388395"/>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Irène</forename>
                    <surname>Ventrillard</surname>
                  </persName>
                  <email type="md5">9ed1f21cecfffad787a3c196defb13f9</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">771600</idno>
                  <idno type="halauthorid" notation="string">829732-771600</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2114-9563</idno>
                  <affiliation ref="#struct-144285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniele</forename>
                    <surname>Romanini</surname>
                  </persName>
                  <email type="md5">364018c9caabfc158310c107a5c669fb</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="string">danielromanini</idno>
                  <idno type="idhal" notation="numeric">844153</idno>
                  <idno type="halauthorid" notation="string">239900-844153</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6874-8304</idno>
                  <idno type="IDREF">https://www.idref.fr/083260471</idno>
                  <idno type="VIAF">https://viaf.org/viaf/201016012</idno>
                  <affiliation ref="#struct-144285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kévin</forename>
                    <surname>Jaulin</surname>
                  </persName>
                  <idno type="halauthorid">1638862-0</idno>
                  <affiliation ref="#struct-569339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascale</forename>
                    <surname>Calabrese</surname>
                  </persName>
                  <idno type="halauthorid">727746-0</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Briot</surname>
                  </persName>
                  <email type="md5">9685ff6c859a05eab240011e2e4426e7</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">808688</idno>
                  <idno type="halauthorid" notation="string">238960-808688</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5579-7665</idno>
                  <idno type="IDREF">https://www.idref.fr/091482127</idno>
                  <affiliation ref="#struct-388395"/>
                  <affiliation ref="#struct-257328"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">89181</idno>
                <idno type="issn">2045-2322</idno>
                <idno type="eissn">2045-2322</idno>
                <title level="j">Scientific Reports</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">9</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <date type="datePub">2019-08-22</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41598-019-48789-8</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep.phy">Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.psr">Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Carbon monoxide (CO) monitoring in human breath is the focus of many investigations as CO could possibly be used as a marker of various diseases. Detecting CO in human breath remains a challenge because low concentrations (&lt;ppm) must be selectively detected and short response time resolution is needed to detect the end expiratory values reflecting actual alveolar concentrations. A laser spectroscopy based instrument was developed (ProCeas) that fulfils these requirements. The aim of this study was to validate the use of a ProCeas for human breath analysis in order to measure the changes of endogenous exhaled CO (eCO) induced by different inspired fractions of oxygen (FiO2) ranging between 21% and 100%. This study was performed on healthy volunteers. 30 healthy awaked volunteers (including asymptomatic smokers) breathed spontaneously through a facial mask connected to the respiratory circuit of an anesthesiology station. FiO2 was fixed to 21%, 50% and 100% for periods of 5 minutes. CO concentrations were continuously monitored throughout the experiment with a ProCeas connected to the airway circuit. The respiratory cycles being resolved, eCO concentration is defined by the difference between the value at the end of the exhalation phase and the level during inhalation phase. Inhalation of 100% FiO2 increased eCO levels by a factor of four in every subjects (smokers and non smokers). eCO returned in a few minutes to the initial value when FiO2 was switched back to 21%. This magnification of eCO at 21% and 100% FiO2 is greater than those described in previous publications. We hypothesize that these results can be explained by the healthy status of our subjects (with low basal levels of eCO) and also by the better measurement precision of ProCeas.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-97332" status="OLD">
          <orgName>Université Grenoble Alpes - UFR Médecine</orgName>
          <orgName type="acronym">UGA UFRM</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci - 38706 La Tronche cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://secteur-sante.univ-grenoble-alpes.fr/medecine/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388395" status="OLD">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-IMAG-PRETA</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-144285" status="OLD">
          <idno type="IdRef">035460849</idno>
          <idno type="ISNI">0000 0000 9272 9931</idno>
          <idno type="RNSR">201122569N</idno>
          <idno type="ROR">https://ror.org/023n9q531</idno>
          <orgName>Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères]</orgName>
          <orgName type="acronym">LIPhy</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>140 rue de la Physique38058 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-liphy.ujf-grenoble.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation name="UMR5588" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-569339" status="INCOMING">
          <orgName>AP2E company</orgName>
          <desc>
            <address>
              <addrLine>Aix-en-Provence</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>